CSA Neurosciences Abstracts

This database enables neuroscientists to keep abreast of major advances within the field and their implications for other medical specialties. The database covers all aspects of vertebrate and invertebrate neuroscience, emphasizing basic research but also including such devastating neural diseases as Alzheimer's.

Subject Coverage

Major areas of coverage include:

Motor Systems
Somatosensory Systems
Pain and Analgesia
Visual Systems
Auditory and Vestibular Systems
Taste, Smell, and Chemical Senses
Electrical and Magnetic Senses
Sonar, Lateral Line, and Other Senses
Neuroanatomy, Histology, and Cytology
Neural Growth and Development
Neurophysiology
Neurochemistry and Cell Biology
Molecular Neurobiology
Neuroendocrinology
Neuroimmunology
Neurogenetics
Neuropharmacology
Neurotoxicology, Drugs of Abuse
Aging, Neurodegeneration, and Repair
Memory, Learning, Neuropsychology, and Language
Alzheimer's Disease and Other Dementias
Experimental Neuropathology
Neural Correlates of Behavior
Neural Networks and Computation
Neuroimaging Techniques
Methods and Apparatus

Dates of Coverage

1982 - currrent

Update Frequency

Monthly, with approximately 1,200 new records added

Size

Over 393,036 records as of February 2007

Print Equivalent

CSA Neurosciences Abstracts (v.1-v.21, 1983-2003)

Supplier

CSA
7200 Wisconsin Avenue
Bethesda, MD 20814 USA
Voice: 800-843-7751 (in N. America)
Voice: +1 301-961-6700 (worldwide)
Fax: +1 301-961-6720
Email: sales@csa.com

Sample Record

TI:	Title Binding of alpha-Synuclein Affects the Lipid Packing in Bilayers of Small Vesicles
AU:	Author Kamp, Frits; Beyer, Klaus
AF:	Author Affiliation Laboratory of Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Ludwig Maximilian University, 80336 Munich, Germany
SO:	Source Journal of Biological Chemistry [J. Biol. Chem.]. Vol. 281, no. 14, pp. 9251-9259. 7 Apr 2006.
IS:	ISSN 0021-9258
EI:	Electronic ISSN 1083-351X
DE:	Descriptors Synuclein; Anisotropy; Temperature effects; Packing; fluorescence spectroscopy; Hydrophobicity; Neurodegenerative diseases; Movement disorders; Cooperativity; Phospholipids; sphingomyelin; Synaptic vesicles; Parkinson's disease; Cholesterol
AB:	Abstract The intracellular deposition of fibrillar aggregates of alpha-synuclein is a characteristic feature of Parkinson disease. Alternatively, as a result of its unusual conformational plasticity, alpha-synuclein may fold into an amphipathic helix upon contact with a lipid-water interface. Using spin label ESR and fluorescence spectroscopy, we show here that alpha-synuclein affects the lipid packing in small unilamellar vesicles. The ESR hyperfine splittings of spin-labeled phospholipid probes revealed that alpha-synuclein induces chain ordering at carbon 14 of the acyl chains below the chain melting phase transition temperature but not in the liquid crystalline state of electroneutral vesicle membranes. Binding of alpha-synuclein leads to an increase in the temperature and cooperativity of the phase transition according to the fluorescence anisotropy of the hydrophobic polyene 1,6-diphenylhexatriene and of the fluorescence emission maxima of the amphiphilic probe 6-dodecanoyl-2-dimethylaminonaphthalene. Binding parameters were obtained from the fluorescence anisotropy measurements in combination with our previous determinations by titration calorimetry (Nuscher, B., Kamp, F., Mehnert, T., Odoy, S., Haass, C., Kahle, P. J., and Beyer, K. (2004) J. Biol. Chem. 279, 21966-21975). We also show that alpha-synuclein interacts with vesicle membranes containing sphingomyelin and cholesterol. We propose that the protein is capable of annealing defects in curved vesicle membranes, which may prevent synaptic vesicles from premature fusion.
LA:	Language English
SL:	Summary Language English
PY:	Publication Year 2006
PT:	Publication Type Journal Article
PB:	Publisher American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA,
CL:	Classification N3 11071 Membranes, receptors, and channels
UD:	Update 200604
SF:	Subfile CSA Neurosciences Abstracts
AN:	Accession Number 6747828
PG:	Journal Pages 9251-9259
JV:	Journal Volume 281
JI:	Journal Issue 14

Field Codes

The following field codes are found in the records of this database. Here they are listed in alphabetical order by two-letter code.

AB = Abstract	LA = Language
AF = Author Affiliation	NT = Notes
AN = Accession Number	NU = Other Numbers
AU = Authors	OT = Original Title
CA = Corporate Author	PB = Publisher
CF = Conference	PT = Publication Type
CL = Classification	PY = Publication Year
DE = Descriptors	SF = Subfile
ED = Editor	SL = Summary Language
ER = Environmental Regime	SO = Source
IB = ISBN	TI = Title
ID = Identifiers	TR = ASFA Input Center Number
IS = ISSN	UD = Update

Contact us

Bharat Book Bureau
207, Hermes Atrium,
Sector 11, Plot No.57,
PO Box.54, CBD Belapur,
Navi Mumbai - 400 614, India.
Phone:+91-(022)-2757 8668 / 2757 9438
Fax:+91-(022)-2757 9131
E-mail: info@bharatbook.com
WebSite: http://www.bharatbook.com