| TI:
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Title
Cell adhesion and prostate tumor-suppressor
activity of TSLL2/IGSF4C, an immunoglobulin
superfamily molecule homologous to TSLC1/IGSF4
|
| AU:
|
Author
Williams, YN; Masuda, M; Sakurai-Yageta, M;
Maruyama, T; Shibuya, M; Murakami, Y |
| AF:
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Author Affiliation
Tumor Suppression and Functional Genomics Project,
National Cancer Center Research Institute, 5-1-1
Tsukiji, Chuo-ku, Tokyo 104-0045, Japan,
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| SO:
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Source
Oncogene [Oncogene]. Vol. 25, no. 10, pp.
1446-1453. 9 Mar 2006 |
| IS:
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ISSN
0950-9232 |
| DE:
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Descriptors
Prostate cancer; Immunoglobulins; Cell adhesion;
IGSF4 protein; Urinary bladder; renal tubules;
Brain; Cell adhesion molecules; Calcium; Confocal
microscopy; Loss of heterozygosity; Homology
|
| AB:
|
Abstract
The TSLL2/IGSF4C encodes an immunoglobulin (Ig)
superfamily molecule showing significant homology
with a lung tumor suppressor, TSLC1. The TSLL2
protein of 55kDa is mainly expressed in the
kidney, bladder, and prostate in addition to the
brain. Here, we report the biological significance
of TSLL2 in the urinary tissues. An
immunohistochemical study reveals that TSLL2 is
expressed at the cell-cell attachment sites in the
renal tubules, the transitional epithelia of the
bladder, and the glandular epithelia of the
prostate. Confocal microscopy analysis
demonstrates that TSLL2 is localized in the
lateral membranes in polarized Mardin-Darby canine
kidney (MDCK) cells. TSLL2 forms homo-dimers and
its overexpression induces aggregation of
suspended MDCK cells in a Ca super(2+)/Mg
super(2+)-independent manner, suggesting that it
is involved in cell adhesion through homophilic
trans-interaction. The TSLL2 gene is mapped on the
chromosomal region 19q13.2, whose loss of
heterozygosity has been frequently reported in
prostate cancer. TSLL2 protein is lost in nine of
nine primary prostate cancers and in a prostate
cancer cell, PPC-1. Introduction of TSLL2 into
PPC-1 strongly suppresses subcutaneous tumor
formation in nude mice. These results suggest that
TSLL2 is a new member of the Ig superfamily cell
adhesion molecules and is a tumor-suppressor
candidate in prostate cancer. |
| LA:
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Language
English |
| SL:
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Summary Language
English |
| PY:
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Publication Year
2006 |
| PT:
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Publication Type
Journal Article |
| PB:
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Publisher
Nature Publishing Group, The Macmillan Building, 4
Crinan Street, London
N1 9XW, UK, |
| DO:
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DOI
10.1038/sj.onc.1209192 |
| CL:
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Classification
B 26416 Other tumor suppressor genes/antioncogenes
|
| UD:
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Update
200605 |
| SF:
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Subfile
Oncogenes & Growth Factors Abstracts |
| AN:
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Accession Number
6759117 |
| PG:
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Journal Pages
1446-1453 |
| JV:
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Journal Volume
25 |
| JI:
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Journal Issue
10 |
