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Conference on CNS Drug Development The future of neuropharmacology


To be held at 15th - 16th December 2008, BSG Conference Centre, London, UK


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Background Information

In the middle of the global economic downturn, the central nervous system drug market is booming. Population growth, better diagnosis and unmet clinical needs mean 70 companies are vying for a market spanning from pain to schizophrenia to obesity.

And, as more of us live longer, the number of people with age-related brain diseases is spiraling. In Europe and the United States alone, this will mean 13.2 million Alzheimer’s and 16.2 million Parkinson’s disease sufferers- worldwide- by 20502.

If effective therapies for such neurodegenerative disorders are not found soon, the fi nancial, societal and emotional costs will be staggering. At the same time, many basic issues in CNS R&D remain unresolved, such as reducing production schedules and compound attrition.

By attending this conference, you will understand how these challenges in CNS drug development are being overcome, as well as:

  • How can drug delivery across the blood-brain barrier be improved?
  • Have new biomarkers been identifi ed to track disease existence or progression?
  • What are the future roles for stem cell and regenerative therapies in lead optimisation?
  • Will creating human-animal cytoplasmic hybrid embryos bring new therapies for neurodegenerative diseases?
  • How can new medicines that improve cognition be validated in clinical trials?
  • Should these drugs be available to the general public?
  • How can we overcome patient heterogeneity?
  • Is there a future for pharmacogenomics in psychiatry?

I look forward to seeing you at the conference.
Yours sincerely

John Shah
Conference Producer

Key Speakers

Jacqueline Hunter, Senior Vice President, Science Environment Development, GlaxoSmithKline
Johan Luthman, TA Head, Neurology, Autoimmune & Infl ammatory Diseases, Merck Serono
Mark Tricklebank, Director, Senior Research Fellow- Psychiatric Disorders Drug Hunting Team, Lilly UK
Leslie Iversen, Department of Pharmacology, University of Oxford
Stephen Minger, Director, Stem Cell Biology Laboratory, King’s College London
Simmone Braggio, Director, Neuroscience CEDD DMPK, GlaxoSmithKline
Peter Jenner, Chief Scientifi c Offi cer, Proximagen
Keith Wesnes, Chief Executive, Cognitive Drug Research
Ann Hayes, Owner, The Ann Hayes Consultancy
Fabrizio Gasparini, Senior Research Investigator, Novartis
John Sinden, Chief Scientifi c Offi cer, ReNeuron
Claude Wischik, Executive Chairman, TauRx Therapeutics
Anders Haegerstand, Chief Scientifi c Offi cer, NeuroNova
Will Spooren, Project Leader, Drug Discovery, Hoffmann-La Roche
Jose de Leon, Director, Research Offi ce, Eastern State Hospital, University of Kentucky
Steve England, Associate Research Fellow, Pfi zer

Who will be there?

Heads, Directors, Senior VPs, CSOs and Project leaders in:

  • CNS Clinical Discovery/Nervous System Research
  • Neuroscience
  • Neurology
  • Psychiatry/Molecular Psychiatry
  • Drug Discovery/Drug R&D/Drug Design
  • Emerging Targets/Lead Optimisation
  • Stem Cell Research/Stem Cell Regulatory Affairs
  • Therapeutics and Molecular Profi ling
  • Pain Management
  • Protein Technologies
  • Pre-Clinical/Clinical R&D
  • Genomics/Proteomics/Bioinformatics/Neuroinformatics
  • Translational Medicine
  • Global Marketing and Medicine
  • Disease Genetics
  • Pharmacology
  • Imaging
  • Immunology/immunotherapy

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DAY 1 : Monday 15th December 2008


09:30 Registration and refreshments


10:00 Opening address from the chair


10:10 CNS drug discovery- where are we and what are the prospects for the future?

  • Medical needs and commercial opportunities in CNS diseases, and exciting new areas in CNS drug discovery
  • Success rates for CNS drug discovery and development
  • Difficulties and potential solutions – exemplified by programmes from several CNS diseases

Ann Hayes
Owner, The Ann Hayes Consultancy
Formerly Head of Drug Discovery, GlaxoSmithKline

10:50 Overcoming the blood-brain barrier in CNS pharmacotherapy

  • Physicochemical barriers to brain penetration- new insights from in silico, in vitro and in vivo models
  • Biological barriers to brain penetration: P-glycoprotein and other transport modulators
  • Establishing the link between blood concentration, receptor occupation and behaviour in preclinical & clinical trials

Simmone Braggio
Director, Neuroscience CEDD DMPK
GlaxoSmithKline


11:30 Morning refreshments

11:50 Biomarkers in CNS R&D

  • Establishing biomarkers of disease existence/progression to improve pipeline efficiency and reduce costs
  • Using biomarkers as part of a portfolio approach
  • Go/no-go decisions and biomarker validation

12:30 Translational medicine and explorative clinical trials in neurology

  • Functional genomics in neuropsychiatric disorders and neuropharmacology
  • Bioinformatics and receptor mechanisms of psychotropic drugs
  • From metabolomics to drug targets
  • The impact of PET/CT & PET/MR on product R&D

Johan Luthman
TA Head, Neurology, Autoimmune & Inflammatory Diseases
Merck Serono

13:10 Networking lunch

14:30 Reducing inflammation in CNS diseases

  • Calor, dolor et rubor: a common theme in neurodegeneration
  • Cytokines and autoimmune inflammation in the brain
  • New insights into pathophysiology and repair in multiple sclerosis

Jonathan Sedgewick
Faculty of Medicine
Imperial College London*

Focus on stem cells in lead optimization

15:10 Using embryonic stem cells (ESCs) to investigate novel drug targets in neurodegenerative disease

  • Modelling disease progression with ESCs
  • Identifying and selecting lead candidates for R&D
  • From toxicity screening to target validation

Stephen Minger
Director
Stem Cell Biology Laboratory, King’s College London

15:50 Afternoon refreshments

16:10 Promoting neurogenesis in neurodegenerative diseases

  • Differentiating and transplanting neural stem cells
  • Ensuring integration of transplanted tissue
  • Therapeutic neurogenesis: insights from the first clinical trials

John Sinden
CSO
ReNeuron

16:50 Neurogenesis and neuroprotection in Parkinson’s disease and amyotrophic lateral sclerosis

  • sNN0031/PDGFBB - towards the clinic to promote neurogenesis and dopamine system restoration
  • sNN0029/VEGF165 - towards the clinic to protect motor neurons in amyotrophic lateral sclerosis
  • Delivering protein drugs to the CNS- pros and cons

Anders Haegerstand
Chief Scientific Officer
NeuroNova


17:30 Closing remarks from the chair

17:40 Networking drinks

Take your discussions further and build new relationships in a relaxed and informal setting.

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DAY 2 : Tuesday 16th December 2008

09:30 Registration and refreshments
10:00 Opening address from the chair

Professor Lon Schneider
Professor of Psychiatry, Neurology and Gerontology
University of Southern California*

10:10 New avenues in pain research

  • Key insights from sodium channel blockers
  • Identifying new drug targets
  • Molecular epidemiology of pain: a new discipline for drug discovery

Steve England
Associate Research Fellow
Pfizer

10:50 Panel discussion: Recent discoveries in affective CNS disorders

  • Parkinson’s disease: Its relevance to the pathophysiology and treatment of affective CNS pathologies
  • Anxiolytics: New results from animal and clinical trials
  • Carbohydrate-based therapeutics for depression, schizophrenia and other affective disorders

Fabrizio Gasparini
Senior Research Investigator
Novartis
Will Spooren
Project Leader, Drug Discovery
Hoffmann-La Roche

11:30 Morning refreshments
11:50 Panel discussion: New targets in Alzheimer’s disease

  • Non-tau approaches: un embarras de richesse?
  • The tangle pathology of AD as a pharmaceutical target

Jacqueline Hunter
Senior Vice President, Science Environment Development
GlaxoSmithKline
Claude Wischik
Executive Chairman
TauRx Therapeutics

12:30 Advances in pre-clinical Parkinson’s disease treatment

Peter Jenner
CSO
Proximagen

13:10 Networking lunch

14:30 Harnessing pre-clinical behavioural neuroscience for drug discovery and bridging the gap to clinical research

Mark Tricklebank
Director, Psychiatric Disorders Drug Hunting Team
Lilly UK

15:10 Cognitive testing in clinical trials

  • Automated equivalents to the MATRICS consensus cognitive battery
  • Selective nicotinic agonists for cognition enhancement
  • Cognitive testing in translational medicine

Keith Wesnes
Chief Executive
Cognitive Drug Research

15:50 Afternoon refreshments

16:10 Personalised prescription in CNS R&D

  • First generation pharmacogenetic tests in psychiatry
  • Current challenges in applying pharmacogenomic tests in clinical practice
  • Future research directions

Jose de Leon
Director, Research Office, Eastern State Hospital
University of Kentucky

16:50 The future of cognition-enhancing drugs

  • Drugs and attention-deficit disorders
  • Preparing for drugs that improve memory, concentration and learning
  • Can ‘smart drugs’ ameliorate cognitive decline and boost memory and creativity?
  • Treating or enhancing?- Ethical implications

Leslie Iversen
Department of Pharmacology, University of Oxford
Formerly Director of the Neuroscience Research Centre
Merck Research Laboratories

17:30 Chair’s closing remarks

17:40 End of conference

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To download conference brochure, please click here..

Fee Per Delegate :

Conference Only

£ 1526.33 Click here to Register

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Bharat Book Bureau
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