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Conference on Colloquium on Obesity Drug Development
13TH - 14TH OCTOBER 2008, BSG CONFERENCE CENTRE, LONDON, UK
Analysing the growing potential for pharmaceuticals to reduce the spread of obesity in a global market

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Dear Colleague,

More than one million prescriptions are being written for obesity drugs in the UK alone, costing £47.5m a year and accounting for nearly 3% of total NHS expenditure. If untreated, obesity and related illnesses can cost many times this amount, so there is understandably a large market for drugs to treat the condition. In the last decade the obesity epidemic has increased rapidly both in terms of proportion of the affected population of affected countries, but also in the number of countries

where there is a cause for concern. Rather than being confined to a handful of developed nations, the disorder now affects many countries worldwide. If you have not yet taken steps in this direction, or you’d like to know how to improve your chances of securing approval for your new products, our lineup of expert speakers at visiongain’s 2008 Obesity Colloquium will be on hand to share their knowledge and experience. This event promises to bring together leaders in the fi eld, so why not take the time to reserve your place now?

However, the market has encountered mixed fortunes in recent years, and lack of adequate reimbursement could foreseeably limit the potential of anti-obesity drugs. By networking with your peers this October, you will fi nd out what steps need to be taken in order to stay competitive, and also to avoid unexpected setbacks. Visiongain’s hotly-anticipated event will enable you to examine the latest technological breakthroughs, discuss and debate scientifi c processes, share expert opinions on all aspects of treatment, and forge the right partnerships for the combating obesity in the coming years

Places are limited, so I invite you to book now to avoid missing out on what promises to be a unique exchange of knowledge and ideas.

I hope to see you there.

Best regards,

Andrea Charles
Head of Conferences

Key Themes

• Learn approaches and emerging options for clinical weight management
• Review the effects of obesity on health and well-being of individuals and communities
• Thoroughly assess obesity and its associated comorbidities
• Examine interventions for the prevention of obesity and evaluate performance to date
• Evaluate treatment approaches and clinical practice
• Recognise obesity phenotypes
• Find out the impact of products for appetite regulation
• Discuss the key impact of Iatrogenesis and weight control
• Determine the optimal use of pharmacotherapy in the management of obesity

Who Should Attend?

By organisation

Pharmaceutical and Biotechnology Companies
Contract Organisations
Sales and Marketing Organisations
Pharmaceutical Associations
Technology Suppliers
Research institutes & Universities
Development and Manufacturing Organisations
Medical Affairs

By job title

Head of Drug Development Strategy
Vice President, Diabetes & Obesity, Clinical R&D
Vice President, Cardiovascular & Metabolic Diseases
Head, New Antidiabetic Agents
Senior Director, Endocrinology & Metabolism
Medical Director, Metabolic Disease Research
Principle Investigator, Department of Metabolic Disorders
Chief Scientific Officer
Director, New Products Global Marketing & Sales
Director of Nutrition/Dieticians/Education
VP of Approval / Regulatory Affairs / Consumer Protection

Implementing gene expression based drug response profiling in clinical trials

Day 1 COLLOQUIUM ON OBESITY DRUG DEVELOPMENT [MONDAY 13TH OCTOBER 2008]

09:00 Registration and refreshments

09:30 Opening address from the chair

Dr. Alina Rodriguez

Dept. of Psychology

Uppsala University

09:40 Examining patient need and drug development

• Obesity and the impact on patient health
• Strategies to address unmet patient needs
• Current weight-loss therapeutics

Professor John Wilding

Head of Diabetes and Endocrinology Research Unit University Hospital

University Hospital Aintree

10.20 The clinical positioning of pharmacotherapy

for obesity

Dr Nick Finer

Clinical Director, Wellcome Clinical Research

Addenbrooke’s Hospital

11:10 Morning refreshments

11:30 Weight loss surgery for severe obesity - A last

resort when drug-based treatments fail

• Physiology of the gastric bypass
• Complications of abdominal surgery
• Nutritional deficiencies
• PAT in the laboratory - case studies

12:10 Obesity and type 2 diabetes

• What can be done and to what extent can it be successful?
• Educating that fat is necessary to store energy in the body
• US Label change to include delay of diabetes type 2 onset information
• Evaluating the link between likelihood and body fatness

Dr. Karin Rimvall

Associate Director, Section for Diabetes and Obesity

AstraZeneca

12:50 Networking lunch

14:00 Introduction to obesity and mental health

• Adiposity and the brain
• Link with emotion and mental health
• Long-term consequences

Dr. Alina Rodriguez

Dept. of Psychology

Uppsala University

14:40 Other complaints and their treatment

• Avoiding respiratory difficulties
• Dealing with chronic musculoskeletal problems
• Treating depression, relationship problems and infertility
• Cardiovascular disease
• Cancers including hormonally related and large bowel
• Reducing the symptoms of gallbladder disease
• Patent control for atherosclerosis treatments

Timothy F Herpin
Director, Metabolic Disease Licensing
Bristol-Myers Squibb

15:20 Afternoon refreshments
15:40 Routes to regulatory approval for metabolic drugs

Professor David J Heal
Director
RenaSci Consultancy, BioCity*

16:20 Panel discussion: Comparing Germany, the UK, US,

Japan, and developing nations

• Discussing the EU Health Commissioner report that more than half of
adults in the EU are currently overweight
• WHO considers obesity to be a worldwide epidemic
• Will the US still have the highest prevalence of obesity in 2015?
• The anti-obesity market in developing nations, and how this affects the
global market now and in the future

Dr. Matthew Coghlan*
Candidate Drug Delivery Team Leader
AstraZeneca

17:00 Closing remarks from the chair

17:05 Networking drinks

Take your discussions further and build new relationships in a relaxed and informal setting.

Day 2 COLLOQUIUM ON OBESITY DRUG DEVELOPMENT [TUESDAY 14TH OCTOBER 2008]

09:00 Registration and refreshments

09:30 Opening address from chair

09:40 Old & new examples of obesity therapy – can we get more effective?

Professor Steve Bloom
Department of Metabolic Medicine
Imperial College London

10:20 Acomplia was rejected by FDA Panel in 2007

– Analysing Sanofi-Aventis’ response
• Factors affecting the decision to withdraw its application temporarily
• How did the anti-obesity market suffer after the withdrawal of Fenfl uramine and Dexfenfl uramine?
• Obstacles facing US Approval for Rimonabant casts a shadow over other obesity drugs
• Analysing the OTC version of Orlistat. approved in the US and involved in a licensing deal with GSK
• Best practices and lessons learned

Dr. Krishna Prasad

Medicines and Healthcare products Regulatory Agency

Department of Health

11:00 Morning refreshments
11:20 Understanding pricing and reimbursement issues

• Will lack of adequate reimbursement limit the potential of anti-obesity drugs?

• Reimbursement for Acomplia - A concern for Sanofi -Aventis?
- The viewpoint from an independent test-house and how it affects the manufacturer’s bottom line
-Discussion of recent results

12:00 Presentation to be announced
12:40 Networking lunch
13:50 Dealing with childhood obesity

• How serious is the problem?
• Analysis of factors, including:
• Genetics
• Environment
• Diet
• Behaviour and regular physical exercise
• Factors affecting childhood prescriptions

Professor Anthony Kafatos

Social Medicine
Preventive Medicine & Nutrition Clinic
University of Crete*

14:30 Understanding energy intake in the obese and

obesogenic behaviour as a pharmacological target

• Is there such as thing as an obesogenic eating style?
• Is appetite regulation different in the obese?
• What are the roles of defi cits in satiety or hedonic aspects of eating in
obesity?
• Intake and eating behaviour as outcome variables in clinical studies

Dr. Jason C.G. Halford

Reader in Appetite and Obesity, Director of the Kissileff Human Ingestive

Behaviour Laboratory School of Psychology

University of Liverpool

15:10 Afternoon refreshments

15:30 Panel Discussion: Phase 2 trials – a thorough roundup

• Novo Nordisk’s Liraglutide
• Sanofi -Aventis’ Surinabant (SR 147778)
• Pfi zer’s CP 741952 and CP 866087
• Alizyme’s Cetilistat (ATL 962)
• Solvay’s SLV 319 (BMS 646256)
• Amylin’s Pramlintide (Symlin, Normylin)
• Kissei’s 869682
• Metabolic’s AOD 9604
• Sanofi -Aventis’ AVE 1625
• Orexigen’s Bupropion/Zonisamide (Empatic/Excalia)

16:00 Pipeline Developments in anti-obesity Treatments

• Genzyme’s GT 389255
• Amgen’s Metreleptin
• VIVUS’ Phentermine/topiramate (MK 0493)
• 7TM Pharma’s TM 30338
• Shionogi’s S 2367
• Obecure’s OBE101
• Discussion of other current pipeline developments

Dr. Hubert C. Chen
Senior Director of Clinical Research
Amylin Pharmaceuticals

16:20 Phase 3 trials – assessing suitability for widespread use

• Merck & Co’s Taranabant
• Pfi zer’s CP 945598
• Orexigen’s Bupropion and Naltrexone (Contrave)
• Arena’s Lorcaserin
• What is the impact on the future?

Dr John Wick Johnson

Director, Licensing & Development

Pfizer

17:00 Chair’s closing remarks and end of conference

Fee Per Delegate  

Conference only

          £1526.33

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