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Dear Colleague,
More than one
million prescriptions are being written for obesity drugs
in the UK alone, costing £47.5m a year and accounting for
nearly 3% of total NHS expenditure. If untreated, obesity
and related illnesses can cost many times this amount, so
there is understandably a large market for drugs to treat
the condition. In the last decade the obesity epidemic has
increased rapidly both in terms of proportion of the
affected population of affected countries, but also in the
number of countries
where there is
a cause for concern. Rather than being confined to a
handful of developed nations, the disorder now affects
many countries worldwide. If you have not yet taken steps
in this direction, or you’d like to know how to improve
your chances of securing approval for your new products,
our lineup of expert speakers at visiongain’s 2008 Obesity
Colloquium will be on hand to share their knowledge and
experience. This event promises to bring together leaders
in the fi eld, so why not take the time to reserve your
place now?
However, the
market has encountered mixed fortunes in recent years, and
lack of adequate reimbursement could foreseeably limit the
potential of anti-obesity drugs. By networking with your
peers this October, you will fi nd out what steps need to
be taken in order to stay competitive, and also to avoid
unexpected setbacks. Visiongain’s hotly-anticipated event
will enable you to examine the latest technological
breakthroughs, discuss and debate scientifi c processes,
share expert opinions on all aspects of treatment, and
forge the right partnerships for the combating obesity in
the coming years
Places are
limited, so I invite you to book now to avoid missing out
on what promises to be a unique exchange of knowledge and
ideas.
I hope to see
you there.
Best regards,
Andrea Charles
Head of Conferences
Key Themes
• Learn
approaches and emerging options for clinical weight
management
• Review the effects of obesity on health and well-being
of individuals and communities
• Thoroughly assess obesity and its associated
comorbidities
• Examine interventions for the prevention of obesity and
evaluate performance to date
• Evaluate treatment approaches and clinical practice
• Recognise obesity phenotypes
• Find out the impact of products for appetite regulation
• Discuss the key impact of Iatrogenesis and weight
control
• Determine the optimal use of pharmacotherapy in the
management of obesity
Who Should
Attend?
By
organisation
Pharmaceutical
and Biotechnology Companies
Contract Organisations
Sales and Marketing Organisations
Pharmaceutical Associations
Technology Suppliers
Research institutes & Universities
Development and Manufacturing Organisations
Medical Affairs
By job title
Head of Drug
Development Strategy
Vice President, Diabetes & Obesity, Clinical R&D
Vice President, Cardiovascular & Metabolic Diseases
Head, New Antidiabetic Agents
Senior Director, Endocrinology & Metabolism
Medical Director, Metabolic Disease Research
Principle Investigator, Department of Metabolic Disorders
Chief Scientific Officer
Director, New Products Global Marketing & Sales
Director of Nutrition/Dieticians/Education
VP of Approval / Regulatory Affairs / Consumer Protection
Implementing gene expression based drug
response profiling in clinical trials
Day 1
COLLOQUIUM ON OBESITY DRUG DEVELOPMENT [MONDAY 13TH
OCTOBER 2008]
09:00
Registration and refreshments
09:30 Opening
address from the chair
Dr. Alina
Rodriguez
Dept. of
Psychology
Uppsala
University
09:40
Examining patient need and drug development
• Obesity and
the impact on patient health
• Strategies to address unmet patient needs
• Current weight-loss therapeutics
Professor John
Wilding
Head of
Diabetes and Endocrinology Research Unit University
Hospital
University
Hospital Aintree
10.20 The
clinical positioning of pharmacotherapy
for obesity
Dr Nick Finer
Clinical
Director, Wellcome Clinical Research
Addenbrooke’s
Hospital
11:10 Morning
refreshments
11:30 Weight
loss surgery for severe obesity - A last
resort when
drug-based treatments fail
• Physiology
of the gastric bypass
• Complications of abdominal surgery
• Nutritional deficiencies
• PAT in the laboratory - case studies
12:10 Obesity
and type 2 diabetes
• What can be
done and to what extent can it be successful?
• Educating that fat is necessary to store energy in the
body
• US Label change to include delay of diabetes type 2
onset information
• Evaluating the link between likelihood and body fatness
Dr. Karin
Rimvall
Associate
Director, Section for Diabetes and Obesity
AstraZeneca
12:50
Networking lunch
14:00
Introduction to obesity and mental health
• Adiposity
and the brain
• Link with emotion and mental health
• Long-term consequences
Dr. Alina
Rodriguez
Dept. of
Psychology
Uppsala
University
14:40 Other
complaints and their treatment
• Avoiding
respiratory difficulties
• Dealing with chronic musculoskeletal problems
• Treating depression, relationship problems and
infertility
• Cardiovascular disease
• Cancers including hormonally related and large bowel
• Reducing the symptoms of gallbladder disease
• Patent control for atherosclerosis treatments
Timothy F
Herpin
Director, Metabolic Disease Licensing
Bristol-Myers Squibb
15:20
Afternoon refreshments
15:40 Routes to regulatory approval for metabolic drugs
Professor
David J Heal
Director
RenaSci Consultancy, BioCity*
16:20 Panel
discussion: Comparing Germany, the UK, US,
Japan, and
developing nations
• Discussing
the EU Health Commissioner report that more than half of
adults in the EU are currently overweight
• WHO considers obesity to be a worldwide epidemic
• Will the US still have the highest prevalence of obesity
in 2015?
• The anti-obesity market in developing nations, and how
this affects the
global market now and in the future
Dr. Matthew
Coghlan*
Candidate Drug Delivery Team Leader
AstraZeneca
17:00 Closing
remarks from the chair
17:05
Networking drinks
Take your
discussions further and build new relationships in a
relaxed and informal setting.
Day 2 COLLOQUIUM ON OBESITY
DRUG DEVELOPMENT [TUESDAY 14TH OCTOBER 2008]
09:00 Registration and
refreshments
09:30 Opening address from
chair
09:40 Old & new examples of
obesity therapy – can we get more effective?
Professor Steve Bloom
Department of Metabolic Medicine
Imperial College London
10:20 Acomplia was rejected
by FDA Panel in 2007
– Analysing Sanofi-Aventis’
response
•
Factors affecting the decision to withdraw its application
temporarily
• How did the anti-obesity market suffer after the
withdrawal of Fenfl uramine and Dexfenfl uramine?
• Obstacles facing US Approval for Rimonabant casts a
shadow over other obesity drugs
• Analysing the OTC version of Orlistat. approved in the
US and involved in a licensing deal with GSK
• Best practices and lessons learned
Dr. Krishna Prasad
Medicines and Healthcare
products Regulatory Agency
Department of Health
11:00 Morning refreshments
11:20 Understanding pricing and reimbursement issues
• Will lack of adequate
reimbursement limit the potential of anti-obesity drugs?
• Reimbursement for
Acomplia - A concern for Sanofi -Aventis?
- The viewpoint from an independent test-house and how it
affects the manufacturer’s bottom line
-Discussion of recent results
12:00 Presentation to be
announced
12:40 Networking lunch
13:50 Dealing with childhood obesity
• How serious is the
problem?
• Analysis of factors, including:
• Genetics
• Environment
• Diet
• Behaviour and regular physical exercise
• Factors affecting childhood prescriptions
Professor Anthony Kafatos
Social Medicine
Preventive Medicine & Nutrition Clinic
University of Crete*
14:30
Understanding energy intake in the obese and
obesogenic
behaviour as a pharmacological target
• Is there
such as thing as an obesogenic eating style?
• Is appetite regulation different in the obese?
• What are the roles of defi cits in satiety or hedonic
aspects of eating in
obesity?
• Intake and eating behaviour as outcome variables in
clinical studies
Dr. Jason C.G.
Halford
Reader in
Appetite and Obesity, Director of the Kissileff Human
Ingestive
Behaviour
Laboratory School of Psychology
University of
Liverpool
15:10
Afternoon refreshments
15:30 Panel
Discussion: Phase 2 trials – a thorough roundup
• Novo
Nordisk’s Liraglutide
• Sanofi -Aventis’ Surinabant (SR 147778)
• Pfi zer’s CP 741952 and CP 866087
• Alizyme’s Cetilistat (ATL 962)
• Solvay’s SLV 319 (BMS 646256)
• Amylin’s Pramlintide (Symlin, Normylin)
• Kissei’s 869682
• Metabolic’s AOD 9604
• Sanofi -Aventis’ AVE 1625
• Orexigen’s Bupropion/Zonisamide (Empatic/Excalia)
16:00 Pipeline
Developments in anti-obesity Treatments
• Genzyme’s GT
389255
• Amgen’s Metreleptin
• VIVUS’ Phentermine/topiramate (MK 0493)
• 7TM Pharma’s TM 30338
• Shionogi’s S 2367
• Obecure’s OBE101
• Discussion of other current pipeline developments
Dr. Hubert C.
Chen
Senior Director of
Clinical Research
Amylin
Pharmaceuticals
16:20 Phase 3
trials – assessing suitability for widespread use
• Merck & Co’s
Taranabant
• Pfi zer’s CP 945598
• Orexigen’s Bupropion and Naltrexone (Contrave)
• Arena’s Lorcaserin
• What is the impact on the future?
Dr John Wick
Johnson
Director,
Licensing & Development
Pfizer
17:00 Chair’s
closing remarks and end of conference
Fee Per Delegate
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