LEDs Used in Biophotonic and Medical Devices Global Market Forecast and Analysis

 Published On: Feb, 2014 |    No of Pages: 562 |  Published By: ElectroniCast Consultants | Format: Excel+PP
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This report by ElectroniCast Consultants provides the research findings of our study of the worldwide consumption of packaged Light Emitting Diodes (LEDs), in Biophotonic and Medical Devices. This report provides global market data covering the years 2013-2020.

The market data are segmented into the following geographic regions, plus a Global summary:

- North, Central and South America (America)
- Europe, plus Middle Eastern and African countries (EMEA)
- Asia Pacific (APAC)

The LED market is segmented into the following sub-application categories:

- Sensing/Detection and Analytical/Monitoring
- Photo-therapy/Sanitation/Cell Regeneration/Curing
- Instrumentation Light Source and Imaging

The market data for are also segmented by the following colors (type):

- Red
- Green
- Blue
- White
- Multiple Color/Multiple Chip
- UV and Other

The term biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light.

Biophotonics has become the established general term for all techniques that deal with the interaction between biological items and photons. This refers to emission, detection, absorption, reflection, modification, and creation of radiation from biomolecular, cells, tissues, organisms and biomaterials. Areas of application are life science, medicine, agriculture, and environmental science.

Similar to the differentiation between "electric" and "electronics" a difference can be made between applications, which use light mainly to transfer energy via light (such as therapy or surgery) and applications which excite matter via light and transfer information back to the operator (like diagnostics). In most cases the term biophotonics is only referred to the second case; however, in this ElectroniCast study, we cover both uses of the LED packaged chips in medical and/or biophotonics:

• Use light mainly to transfer energy via light (such as therapy or surgery)

• Applications which excite matter via light and transfer information back to the operator, such as diagnostics

LED Level Quantified in the ElectroniCast Study Below, are five levels (or “food chain”) of LEDs. For the purposes of THIS ElectroniCast study, we quantify and provide a market forecast for “Level 2”

Level 1 - The chip or die
Level 2 - The Packaged LED (component-level bulb)
Level 3 - LED array; may include optics, heat sink, other components
Level 4 - Lamp (consumer-level bulb)
Level 5 - LED luminaire (light fixture/light fitting)

This report provides the market data by the following functions:

• Consumption Value (US$, million)
• Quantity (number/units)
• Average Selling Prices (ASP $, each)

The value is determined by multiplying the number of units by the average selling price (ASP). The ASPs are based on the price of the packaged LED at the initial factory level (prior to FOB – Free On Board). The value is then based on the end-use application and the end-use region.

This study is based on analysis of information obtained continually over the past several years, but updated through the beginning of February 2014. During this period, ElectroniCast analysts performed interviews with authoritative and representative individuals in the following sectors relative to the use of LEDs: medical, science, bio-photonic, display industry, test/measurement, instrumentation, R&D, university, military defense and government. The interviews were conducted principally with:

• Engineers, marketing personnel and management at manufacturers of LED test/measurement & medical science equipment/devices and related equipment, as well as other technologies

• Design group leaders, engineers, marketing personnel and market planners at major users and potential users of LEDs and test/measurement & medical science equipment/devices

• Other industry experts, including those focused on standards activities, trade associations, and investments.

The interviews covered issues of technology, R&D support, pricing, contract size, reliability, documentation, installation/maintenance crafts, standards, supplier competition and other topics.

Table of Contents

1. LEDs Used in Biophotonic and Medical Devices Executive Summary 1-1
1.1 Overview 1-1
1.2 Bare (Unpackaged) LED Chips – Overview 1-17
2. LEDs – Technology Overview 2-1
3. LEDs Used in Biophotonic and Medical Devices Market Forecast 3-1
3.1 Overview 3-1
3.2 Sensing/Detection and Analytical/Monitoring 3-9 3-
3.3 Photo-therapy/Sanitation/Cell Regeneration/Curing 3-114
3.4 Instrumentation Light Source and Imaging 3-159
4. Fiber Optic Sensor Technology 4-1
4.1 Overview 4-1
4.2 Interferometric Fiber Optic Sensors 4-6
4.3 Intensity Fiber Optic Sensors 4-28
4.4 Polarization Fiber Optic Sensors 4-31
4.5 Fiber Bragg Grating (FBG) Fiber Optic Sensors 4-35
4.6 Raman Scattering Fiber Optic Sensors 4-59
4.7 Fluorescence Fiber Optic Sensors 4-66
4.8 Brillouin Scattering Fiber Optic Sensors 4-78
4.9 Doppler Anemometry 4-81
4.10 Spectroscopy 4-85
4.11 Waveguides Fiber Optic Sensors 4-95
4.12 Optrode 4-131
4.13 List of Fiber Optic Sensor and Related Companies (over 130 companies listed with web-links) 4-144 4-144
5. Company Profiles of Pulse Oximeter Suppliers (47-companies) 5-1 5-1
6. Market Research Methodology 6-1
7. Definitions and Standards (LEDs) 7-1
7.1 Acronyms, Abbreviations, and General Terms 7-1
7.2 Lighting Standards and Protocols 7-73
8. Market Forecast Data Base 8-1
8.1 Overview 8-1
8.2 Tutorial 8-3

Addendum
Excel Data Base Spreadsheets (Global Market Forecast)
Detailed Data: ASP ($, each); Quantity (Million); Value ($, Million) for all Regions
Power Point Market Data Figures (Global Market Forecast)

List of Tables

1.1.1 LEDs in Medical/Biophotonic Devices Global Forecast, By Application ($, Million) 1-4
2.1 LED Color Variety – Selected Examples 2-9
2.2 LED Color Chart 2-11
3.1.1 LEDs in Medical/Biophotonic Devices Global Forecast, By Application ($, Million) 3-4
3.1.2 LEDs in Medical/Biophotonic Devices Global Forecast, By Application (Quantity/Units) 3-5
3.1.3 LEDs in Medical/Biophotonic Devices America Forecast, By Application ($, Million) 3-6
3.1.4 LEDs in Medical/Biophotonic Devices America Forecast, By Application (Quantity/Units) 3-6
3.1.5 LEDs in Medical/Biophotonic Devices EMEA Forecast, By Application ($, Million) 3-7
3.1.6 LEDs in Medical/Biophotonic Devices EMEA Forecast, By Application (Quantity/Units) 3-7
3.1.7 LEDs in Medical/Biophotonic Devices APAC Forecast, By Application ($, Million) 3-8
3.1.8 LEDs in Medical/Biophotonic Devices APAC Forecast, By Application (Quantity/Units) 3-8
3.2.1 LEDs in Sensing/Detection and Analytical/Monitoring Global Forecast, By Application ($, Million) 3-9
3.2.2 LEDs in Sensing/Detection and Analytical/Monitoring Global Forecast, By Application (Quantity) 3-10
3.2.3 LEDs in Sensing/Detection and Analytical/Monitoring America Forecast, By Application ($, Million) 3-11
3.2.4 LEDs in Sensing/Detection and Analytical/Monitoring America Forecast, By Application (Quantity) 3-11
3.2.5 LEDs in Sensing/Detection and Analytical/Monitoring EMEA Forecast, By Application ($, Million) 3-12
3.2.6 LEDs in Sensing/Detection and Analytical/Monitoring EMEA Forecast, By Application (Quantity) 3-12
3.2.7 LEDs in Sensing/Detection and Analytical/Monitoring APAC Forecast, By Application ($, Million) 3-13
3.2.8 LEDs in Sensing/Detection and Analytical/Monitoring APAC Forecast, By Application (Quantity) 3-13
3.2.9 Strain Sensing Technology Attributes Summary 3-24
3.3.1 LEDs in PDT/Sanitation/Cell Regeneration/Curing Global Forecast, By Application ($, Million) 3-115
3.3.2 LEDs in PDT/Sanitation/Cell Regeneration/Curing Global Forecast, By Application (Quantity) 3-116
3.3.3 LEDs in PDT/Sanitation/Cell Regeneration/Curing America Forecast, By Application ($, Million) 3-117
3.3.4 LEDs in PDT/Sanitation/Cell Regeneration/Curing America Forecast, By Application (Quantity) 3-117
3.3.5 LEDs in PDT/Sanitation/Cell Regeneration/Curing EMEA Forecast, By Application ($, Million) 3-118
3.3.6 LEDs in PDT/Sanitation/Cell Regeneration/Curing EMEA Forecast, By Application (Quantity) 3-118
3.3.7 LEDs in PDT/Sanitation/Cell Regeneration/Curing APAC Forecast, By Application ($, Million) 3-119
3.3.8 LEDs in PDT/Sanitation/Cell Regeneration/Curing APAC Forecast, By Application (Quantity) 3-119
3.3.9 Therapeutic Visible Light Spectrum 3-132
3.4.1 LEDs in Instrumentation Light Source and Imaging Global Forecast, By Application ($, Million) 3-161
3.4.2 LEDs in Instrumentation Light Source and Imaging Global Forecast, By Application (Quantity) 3-162
3.4.3 LEDs in Instrumentation Light Source and Imaging America Forecast, By Application ($, Million) 3-163
3.4.4 LEDs in Instrumentation Light Source and Imaging America Forecast, By Application (Quantity) 3-163
3.4.5 LEDs in Instrumentation Light Source and Imaging EMEA Forecast, By Application ($, Million) 3-164
3.4.6 LEDs in Instrumentation Light Source and Imaging EMEA Forecast, By Application (Quantity) 3-164
3.4.7 LEDs in Instrumentation Light Source and Imaging APAC Forecast, By Application ($, Million) 3-165
3.4.8 LEDs in Instrumentation Light Source and Imaging APAC Forecast, By Application (Quantity) 3-165

List of Figures

1.1.1 LEDs in Medical/Biophotonic Devices Global Forecast ($, Million) 1-3
1.1.2 LEDs in Medical/Biophotonic Devices Global Forecast, By Application ($, Million) 1-5
1.1.3 LEDs in Medical/Biophotonic Devices Global Forecast, By Region ($, Million) 1-6
1.1.4 Single-die LED: 1000 lm at 100 lm/W at 3A 1-7
1.1.5 Four-die LED with Primary Optics 1-8
1.1.6 Example of LED Packaged Chip (Component-Level) Bulb 1-9
1.1.7 Example of LED Packaged Chip (Component-Level) Bulb 1-9
1.1.8 Example of LED Packaged Chip (Component-Level Bulb) Surface Mount Variations 1-10
1.1.9 Example of LED Packaged Chip: Flux (Component-Level Bulb) 1-11
1.1.10 Example of High Brightness LED Packaged Chip (Component-Bulb) 1-12
1.1.9 LEDs in Medical/Biophotonic Devices Global Forecast, By Color ($, Million) 1-13
1.1.10 LEDs in Medical/Biophotonic Devices America Forecast, By Color ($, Million) 1-14
1.1.11 LEDs in Medical/Biophotonic Devices EMEA Forecast, By Color ($, Million) 1-15
1.1.12 LEDs in Medical/Biophotonic Devices APAC Forecast, By Color ($, Million) 1-16
1.2.1 Diagram of a typical LED chip 1-17
1.2.2 Diagram of a typical LED chip 1-18
1.2.3 LED Chip Cross-Sectional Structure 1-19
1.2.4 Chip On Glass Cross-Sectional Structure 1-20
1.2.5 ESD Protection Diodes 1-21
1.2.6 Electrostatic Discharge Example 1-22
1.2.7 Chip-on-Board LED Technology 1-23
2.1 RPCVD Process Equipment 2-5
2.2 LED Chromatic Chart 2-11
2.3 Evolution of Research Emphasis During Technology Life Cycle 2-13
2.4 LED Chip: Metal Layer (Thin Film Technology) 2-14
2.5 Vertical LED Chip 2-15
2.6 AC LED Technology on a Wafer 2-21
2.7 Ultra High Bright LED Chip 2-22
2.8 LED Chip Design with Copper Alloy Thermal Conductivity 2-23
2.9 LED Chip Design – Sapphire vs. Copper Alloy 2-24
2.10 Ultra-Thin LED 2-26
2.11 Solid-State Lighting LED 2-27
2.12 LED Module with High Light Quality 2-28
2.13 Lumiramic Phosphor Technology: Thin Film Flip Chip (TFFC) technology 2-31
2.14 Next-Generation Light Emitting Diode Module 2-38
2.15 4-Leaded RGB LED 2-40
2.16 Basic Structure of a Deep-UV Light-Emitting Diode 2-44
2.17 Vertically Conducting Advanced LED Structure 2-45
2.18 AlGaInP LED Efficacy 2-47
2.19 Red Nitride Phosphors 2-49
3.1.1 LEDs in Medical/Biophotonic Devices Global Forecast ($, Million) 3-2
3.1.2 LEDs in Medical/Biophotonic Devices Global Forecast (Quantity/Units) 3-3
3.2.1 Fabry-Perot Fiber-Optic Temperature-Sensor 3-26
3.2.2 Fiber Optic Temperature Sensor 3-28
3.2.3 Fiber Optic Cable with Temperature Sensor 3-29
3.2.4 Upgradeable Mulichannel Fibre Optic Thermometer 3-30
3.2.5 Pre-clinical Transducer with Fiber Coating 3-35
3.2.6 Sealed-Gauge Fiber Optic Pressure Sensors 3-36
3.2.7 Fiber Optic Sensor would be implanted through the skin 3-41
3.2.8 Optical Fibers Bundled with a Capillary Tube 3-43
3.2.9 Surgery Fiber Optic Sensor – Probe 3-47
3.2.10 Vibration optical fiber sensors classification 3-51
3.2.11 Fiber-optic Vibration & Displacement Sensor 3-57
3.2.12 Fiber Optic Position Sensor (FOPS) 3-58
3.2.13 Fiber Optic Position Sensor (FOPS) 3-63
3.2.14 Magneto-Optic Current Transformer for Protection (MOCT-P) 3-67
3.2.15 Mini-sensor measures magnetic activity in human brain 3-68
3.2.16 Microfiber Knot Resonator 3-71
3.2.17 Seven (7) wavelengths acquire blood constituent data 3-78
3.2.18 Seven (7) wavelengths acquire blood constituent data 3-78
3.2.19 Oximeters - Upgradable Technology Platforms 3-79
3.2.20 Automated Flying-Insect Detection System (AFIDS) 3-86
3.2.21 Non-invasive Sensing 3-88
3.2.22 FLIPPER - light-emitting diode excites fluorescence in the sample flow cell 3-92
3.2.23 Nano-sized "carbon dots" glow brightly when exposed to light 3-95
3.2.24 Variable wavelength HPLC/CE detector 3-101
3.2.25 Led-Based Direct Visualization of Tissue Fluorescence 3-112
3.2.26 LED-Based Cell Phone Sensor for Detection of E. coli 3-113
3.3.1 Handheld LED Light Therapy Rejuvenation Device 3-127
3.3.2 Neonatal Phototherapy Treatment (Blue LEDs) 3-129
3.3.3 Light doses range in LED Phototherapy 3-131
3.3.4 Skin treatment therapies Utilizing LED Photo-modulation: Typical LED array (Red) 3-135
3.3.5 Blue LED Arrays 3-139
3.3.6 Apparatuses Containing Arrays of LEDs 3-145
3.3.7 UV LED Disinfection 3-156
3.4.1 LEDs – Different Colors for Fluorescence Microscopy Applications 3-166
3.4.2 LED versus Tungsten used in Slit Lamps Retina Observation 3-170
3.4.3 Red, Green and Blue LED Light Sources – Biophotonics 3-171
3.4.4 Ring Light 3-173
3.4.5 LED-Based Fiber Optic Illuminator 3-174
3.4.6 LED-Based Fiber Optic Illuminator 3-175
4.2.1 Schematic Drawing: Fiber-optic Fabry-Perot Interferometers 4-10
4.2.2 Schematic Drawing: Fiber-optic Fabry-Perot Interferometers 4-11
4.2.3 All-Fiber Michelson interferometer 4-12
4.2.4 Measurement of Micron-Scale Deflections 4-13
4.2.5 Michelson Type-Interferometer with Improvements 4-18
4.2.6 Traditional Fourier-Transform Spectrometer 4-21
4.2.7 Electro-Optical Imaging Fourier-Transform Spectrometer 4-22
4.5.1 Structure of a Fiber Bragg Grating 4-34
4.5.2 Fabry-Perot Sensor Fabricated by Micro-machining 4-36
4.5.3 Unpackaged FBG Sensor 4-38
4.5.4 Weldable FBG Strain Sensor 4-39
4.5.5 Hydrostatic Pressure and Temperature Measurements FBG Sensor 4-40
4.5.6 Flexible Optical Sensing 4-41
4.5.7 Bridge Scour Monitoring: FBG Sensors 4-43
4.5.8 Real-Time Train Wheel Condition Monitoring Scheme 4-44
4.5.9 Fiber Bragg Grating (FBG) Sensors Used in Sailing 4-45
4.6.1 Hand-Held Raman Scanner 4-52
4.7.1 Fluorescent Long-Line Fiber Optic Position Sensors 4-60
4.7.2 Fluorescent Long-Line Fiber Optic Position Sensors with LED 4-62
4.9.1 Laser Doppler Flowmetry 4-69
4.9.2 Schematic Representation of Zeta Potential 4-71
4.10.1 Schematic of a LIBS system 4-77
4.11.1 Surface Plasmon Sensors 4-80
4.11.2 Polariton fiber sensor configuration 4-83
4.11.3 Polariton Fiber Sensor 4-84
4.11.4 Tapered fiber structure with uniform waist 4-85
4.11.5 Surface Plasmon Resonance Sensing Structure 4-86
4.11.6 Hollow core sensing structure with Bragg grating 4-87
4.11.7 Planar SPP sensor with Bragg grating imprinted into the waveguide layer 4-89
4.11.8 Planar SPP sensor with LPG imprinted into the waveguide layer 4-91
4.11.9 MZI branch with the Bragg grating 4-93
4.11.10 Dependence between the refractive index 4-94
4.11.11 A dual LPG-based SPR sensor 4-95
4.11.12 Tilted grating assisted SPR sensor 4-97
4.11.13 Changes in the Intensities 4-98
4.11.14 PVDF Coated Teflon Fiber SPR Gas Sensor 4-99
4.11.15 Hybrid Mode SPR Sensor 4-100
4.11.16 Thin SPP Waveguide 4-101
4.11.17 Gemini Fiber 4-107
4.11.18 Specialty Optical Fibers with Holes for sensors, lasers and components 4-108
4.11.19 Fiber Sensor: LPG and HiBi Fiber 4-110
4.12.1 Use of an Optrode 4-116
5.1 Pulse Oximeter 5-2
5.2 Fingertip Pulse Oximeter 5-3
5.3 Veterinarian Oximeter 5-5
5.4 Handheld Pulse Oximeter 5-6
5.5 Portable Pulse Oximeter 5-8
5.6 Fingertip Oximeter 5-12
5.7 Pulse Oximeter 5-15
5.8 Finger Pulse Oximeter 5-16
5.9 Fingertip Pulse Oximeter 5-19
5.10 Wrist Pulse Oximeter 5-21
5.11 Portable Digital Oximeter with Probe 5-22
5.12 Pulse Oximeter 5-24
5.13 Handheld Pulse Oximeter with Finger Sensor 5-26
5.14 Finger Pulse Oximeter 5-27
5.15 Finger Pulse Oximeter 5-28
5.16 Hand Held Pulse Oximeter 5-31
5.17 Seven (7) wavelengths acquire blood constituent data 5-34
5.18 Seven (7) wavelengths acquire blood constituent data 5-35
5.19 Oximeters - Upgradable Technology Platforms 5-36
5.20 Handheld and Tabletop Oximeters 5-41
5.21 Multi-Functional Monitor, including Oximeter Probes 5-43
5.22 Hand Held Pulse Oximeter 5-44
5.23 Desktop Pulse Oximeter 5-46
5.24 Portable Capnography Monitor 5-48
5.25 Fingertip Pulse Oximeter 5-50
5.26 Hand-Carry Monitor with Oximeter 5-52
5.27 Fingertip Pulse Oximeter 5-53
5.28 Monitor System with Oximeter 5-54
5.29 Hand Held Pulse Oximeter 5-55
5.30 Hand-Held Capnograph/Oximeter 5-57
5.31 Fingertip Pulse Oximeter 5-61
5.32 Hand Held Pulse Oximeter 5-62
5.33 Hand Held Pulse Oximeter 5-64
5.34 Hand Held Pulse Oximeter 5-66
6.1 Market Research & Forecasting Methodology 6-2

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