Medication Adherence: Systems, Technologies and Global Markets

 Published On: Nov, 2017 |    No of Pages: 166 |  Published By: BCC Research | Format: PDF
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The global market for medication adherence reached $1.7 billion in 2016 and should reach nearly $4.0 billion by 2021 at a compound annual growth rate (CAGR) of 18.0% from 2016 through 2021.

Report Includes

-16 data tables and 24 additional tables
-An overview of the global medication adherence market
-Analyses of global market trends, with data from 2015 and 2016, and projections of compound annual growth rates (CAGRs) through 2021
-Evaluations of clinical needs, competitive landscape, unmet needs, regulatory structure, and future outlook
-Examinations of the product types and the disease applications for medication adherence, along with chronic disorders
-Evaluations of the market's dynamics, specifically growth drivers and restraints
-Profiles of major players in the industry

Chapter 1: Introduction
Medication adherence refers to the conformance of patients to take the medication prescribed by their healthcare providers at the correct dosage and timing. Medication non-adherence is an important public health concern, affecting health outcomes and overall healthcare costs for several chronic diseases, such as diabetes and asthma. Half of all patients do not take their medications as prescribed and more than one in five new prescriptions go unfilled. As per estimates, total potential savings from adherence and related disease management could be $300 billion annually in the U.S. alone, which is 13% of health spending.

Improved adherence can be achieved through better education, value-based insurance designs, use of patient incentives and adoption of medication adherence systems including hardware-based medication adherence systems (e.g., smart pill bottle, smart caps, automated pill dispenser, electronic tray, smart cabinets, smart medical watches, smart medical alarms, wearable health sensors, packaging system and other pharmacist-led medication therapy management systems) and software applications (e.g., mobile apps, sensor enabled software solutions, mobile medication management applications, patient portals, health programs, web portals and others). E-prescribing is another intervention with the potential to improve medication adherence and decrease total healthcare costs, and is becoming more widely used as electronic medical records are integrated into medical practices.

Study Goals and Objectives
This study, Medication Adherence: Systems, Technologies and Global Markets, provides an overview of hardware-based medication adherence systems, software-based internet applications (apps) and their uses in medication adherence and management. In addition, it gives a detailed analysis of the competitive environment. It covers a wide variety of hardware-based systems and software-based internet applications that greatly improve the medication adherence in the treatment of diseases and disorders. This study includes information about emerging medication adherence technologies, market players, issues, and trends, and offers other information affecting the healthcare, pharmaceutical and medical device industry.

The study meets the criteria above by analyzing the global healthcare, pharmaceutical and medical device industry in light of the most recently available information. In addition to looking at current and future markets, this report analyzes the technological, demographic and economic developments that may have a long-term impact on the size and structure of the healthcare, pharmaceutical and medical device market. The future of medication adherence is also discussed with forecasts.

More specific objectives are to:

-Identify and segment the key medication adherence systems and technologies used for improving medication adherence.
-Analyze current and future device technologies by market segments.
-Identify and evaluate the impact of demographic, economic and other factors that will drive future demand for the medication adherence systems and technologies market.
-Identify promising new medication adherence systems and software applications still in the development and testing stages, and assess the probability that they will be commercialized successfully in the next five years.
-Forecast the potential market based on pipeline devices, taking into account the estimated probability that they will be commercialized.

This study will provide the reader with the knowledge to adequately view and assess smart pills and provide insights into their market potential.

Reasons for Doing This Study
Medication non-adherence remains a common healthcare problem across developed and developing nations. It is one of the major public health concerns that adversely impacts patient outcomes, increases healthcare utilization and associated costs. According to the CDC, about 20% to 30% of medication prescriptions are never filled, and about half of all prescribed medications are not continued as prescribed. More than 80% of patients leave a physician’s office with a prescription in hand, but as many as half of all patients do not take their medications as prescribed. Poor adherence causes approximately 30% to 70% of medication-related hospitalizations and accounts for more than $300 billion in annual healthcare costs in the U.S. alone. Patients are considered adherent when they take their prescribed medications at doses and times recommended by their healthcare provider.

Pharmaceutical, medical device and healthcare providers are turning to medication adherence systems and software application to deal with the current challenges associated with medication non-adherence. Dispensing cabinets & dispensers automate the management and dispensing of medications while smart pill bottles help in dispensing the right medication at the right time, in the right quantity with the right instructions. Increasing acceptance of medication therapy management systems, smart pill bottles, smart caps, automated pill dispensers, electronic trays, smart medical watches, smart medical alarms, wearable sensors, specialized packaging systems and software-based internet applications (cloud-based databases, web portals and mobile application) are helping patients, payers and providers with management, dispensing and monitoring of medications.

Overall, medication adherence systems offer improved drug adherence, real-time data monitoring, logical calculations, and network communication. Medication adherence systems can be categorized into two major segments: hardware-based medication adherence systems and software-based internet applications (apps). The growth of the medication adherence systems market is being driven mainly by factors, such as the growing elderly population, the rising prevalence of chronic diseases, the widespread adoption of smartphones and other technological advancements within the life sciences industry.

The U.S. dominates the global medication adherence market, followed by Europe, Asia and the rest of the world (ROW). The large market shares of U.S. and Europe can be attributed to a greater accessibility of advanced technologies and the presence of a large number of leading market players. The growth of the medication adherence systems and technology field during the forecast period is reflective of an increasing population and rising healthcare needs, escalated healthcare spending, improvement of regional infrastructure, and growing investments by the leading players and respective government agencies.

This report is the first edition to cover medication adherence systems and technologies in order to improve medication adherence, with analysis of its key growth areas and quantitative market projections of technologies and devices. This study attempts to provide the reader with information about and analysis of medication adherence systems and their applications in dealing with today’s current challenges associated with medication non-adherence.

Scope of Report
Medication adherence include hardware-based systems (e.g., smart pill bottle, smart cap, automated pill dispenser, electronic trays, smart medical watches, smart medical alarms, wearable sensors, and other packaging systems) and software based internet applications (e.g., cloud-based databases, health programs, patient web portals, mobile medication management applications, etc.) to improve medication adherence associated with various chronic diseases. This report is an analytical business tool whose primary purpose is to provide a thorough evaluation of the global market for medication adherence. The format of this study includes the following:

-Detailed description of medication adherence systems and technologies including software applications (apps).
-Demographics and cost burden of targeted chronic diseases.
-Market characterization, unmet need, market size, and segmentation.
-Market drivers and restraints.
-Detailed market projections through 2021.
-Competition and market shares.
-Key marketed and pipeline (R&D) products along with information about their regulatory status
-Strategic landscape (Merger and acquisitions).
-Regulatory structure.
-Pricing and reimbursement.
-Observations and conclusions on the future of medication adherence systems and technologies.
-Profiles of market participants and associations.

Information Sources
This report has been written for vendors of the healthcare, pharmaceutical and advanced medical equipment sector seeking to understand the potential market for their products and their competitors’ products in key markets, as well as for governmental and international agencies seeking to understand the commercial and medical potential of medication adherence systems and software technologies (software apps). This study is especially intended for readers in the:

-Healthcare, pharmaceutical and medical device industry.
-Executive management and marketing community.
-Medical research institution community.
-Investment community.
-Financial and business analyst community.

Methodology and Information Sources
The findings and conclusions of this report are based on information gathered through primary and secondary data collection methods. Primary methods included interviews with key executives, product managers, clinical specialists, and other related key personnel involved in the healthcare, medical device and diagnostics industry. Secondary sources included published literature, investment reports, trade publications, trade associations, company literature, online databases, and various business journals on related medical devices and diagnostic areas. All of these sources were used to produce the market estimates contained in this report.

Market forecasts were developed for 2016 to 2021, using 2016 as a baseline. These projections were based on a consensus of primary contacts together with the expertise of BCC Research in the area of key market drivers and their impact from a historical and analytical perspective. The analytical methodologies used to generate the market estimates are described comprehensively in the section on detailed market projections. All dollar projections presented in this report are in 2016 constant dollars.

Geographic Breakdown

In this report, the geographic regions considered for market analysis are limited to:

-North America.
-Europe.
-Asia.
-Rest of the World (ROW).
Chapter 1: Introduction 1
Study Goals and Objectives 1
Reasons for Doing This Study 2
Scope of Report 3
Information Sources 3
Methodology and Information Sources 4
Geographic Breakdown 4
Analyst's Credentials 8
Related BCC Research Reports 8

Chapter 2: Summary and Highlights 10

Chapter 3: Target Diseases and Disorders 16
Cardiovascular Diseases (CVD) 16
Angina Pectoris 16
Stroke 17
Hypertension 18
Musculoskeletal Disorders 20
Epidemiology and Economic Burden 20
Mortality 22
Gastrointestinal/Digestive Diseases 24
Epidemiology and Economic Burden 24
Mortality 24
Common Gastrointestinal Diseases and Disorders 25
Inflammatory Bowel Disease (IBD) 25
Ulcer Disease 26
Esophagitis/Esophageal Diseases 27
Gastroesophageal Reflux Disease (GERD) 27
Obscure Gastrointestinal Bleeding 28
Celiac Disease 29
Breast Cancer 29
Colorectal Cancer 32
Small-bowel Tumors/Diseases 37
HIV/AIDS 37
Asthma and Chronic Obstructive Pulmonary Disease (COPD) 38
Diabetes 39
Disease Symptoms and Risk Factors 40
Obesity 42

Chapter 4: Medication Non-adherence 49
Medication Non-adherence 49
Medication Non-adherence Categories 49
Economic Burden/Cost of Medication Non-adherence 50
Measurement of Adherence 51
Cost-related Non-adherence 51
Medication Adherence and Non-economic Factors 51
Cost and Morbidity in Chronic Disease Medication Non-adherence 51
Methods to Improve Medication Adherence 52
Traditional Digital Reminders 52
User Counseling and Behavioral Interventions 52
Medication Adherence and Smartphones 53
Effectiveness of Smartphone Adherence Apps 53
Other General Guidelines to Improve Adherence 53
Future Developments 54

Chapter 5: Medication Adherence Systems 56
Medication Non-adherence 56
Hardware-centric Medication Adherence Systems 56
Type of Medication Adherence Systems 56
Smart Pill Bottles 57
Automated Pill Dispensers 57
Electronic Trays 57
Smart Caps 58
Smart Pills 58
Other Adherence Devices and Solutions 58
Key Marketed and Pipeline Products 58
Omnicell VBM 200F 58
Omnicell XT Automated Medication Dispensing Cabinets 59
OmniRx Automated Medication Dispensing Cabinets 59
Robot-Rx Medication Dispensing Solution 59
AcuDose-Rx Automated Medication Dispensing Cabinets 59
Didit 59
DoseCue Containers 60
Med-IC Electronic Compliance Monitor 60
eCAP Information Mediary Corp.’s eCAP is a smart bottle designed for senior patients. It is child-
resistant and can dispense solid or liquid doses. It can be read and accessed using a smart device. 60
Med-IC eDiary 60
ePill Automatic Medication Dispensers and Pill Boxes 60
ID-Capsule 61
iRemember 62
Vitality GlowCap 62
MedCenter Monthly Pill Organizer 62
Med-E-Lert Reminder and Dispenser 62
MedMinder Pill Dispensers 62
MedStart Connect 63
CleverCap 63
Kraken Medication Monitoring System 64
Propeller 64
Medimi Dispenser 64
Medimi Smart 64
Medication Dispensing Systems (from Manrex Ltd.) 65
Silent Knight, Calm-Press, Powdercrush (from Manrex Ltd.) 65
Electronic Medication Management Assistant 65
Smart Pill Bottles 66
Nomi 66
PillStation 67
MedaCheck Medication Management 67
TalkingRx 67
Take-n-Slide dose tracker 67
Talking Pill Reminder 67
Target Prescription Bottle 67
Tel-Rx 68
Timex 2 68
Smartinjector 68
TowerView Pillbox 69
Proteus Patch 69
Abilify Smart Pill 70
Smart Pill (Novartis Drugs + Proteus Ingestible Sensor) 70
IntelliCap 71
Novartis Robotic Pill 71
Novartis Smart Pill) 71
uBox 72
Reminder Rosie 72
PillBill 72
Livi 73
PreciseMeds Personal Pill Dispenser 73
PillTime Medical Adherence Device 73
Pillpresso 74
MODO Pill Dispenser 74
CapsulePen 74
Smartinhaler 74
PillDrill Smart Medication Tracking 75
Rowa Dose System 75
Inspiration 626 75
PillsyCap 75
Biodose System 75
SentryPal Mobile Medical Alert Systems 76
Medication Management Systems 76
HealthAssist Watch 76
RxPense Home Medication Dispenser 76
SimpleMedRx 76
Challenges to Improving Medication Adherence with Technology 77
Future Developments 77

Chapter 6: Software Applications 79
Medication Adherence and Software Applications 79
Types of Software and Internet Applications 79
Mobile and Digital Applications 79
Internet Web Portals and Platforms 79
Communications Solutions 79
Big Data Solutions 80
Other Tools 80
Advantages of Software and Mobile Applications 80
Interconnectivity of Adherence Apps 81
Effectiveness of Smartphone Adherence Apps 81
Key Marketed and R&D Pipeline Products 81
Software and Support Applications 81
Glooko Remote Patient Monitoring Platform 81
Diasend Clinic 82
Diasend Personal 82
Memotext 82
HealthPrize Action Engine 82
Omada 82
DoseCue Services (from DoseCue LLC) 83
CertiScan 83
Quand Medication Compliance Software 84
HealthAssist 84
AirStrip ONE 84
AirStrip Accelerator Services 84
Patient Advisor 85
RxAdvance Platform 85
Pega Care Management 85
StarWellness (Med Sync) 86
MTM Assist 86
PrescribeMedicare 86
MedAdvisor 86
Healthnotes App 86
Rx&You 86
Mango Health 87
Know My Meds 87
Patient list and reminder system 87
PillFill 87
PatientPartner 87
MedPal 87
PillCast 88
Monitor My Meds 88
RxNetwork 88
Adherence 88
eNURZ 88
Mscripts 88
MobiDawa 89
SafeText 89
Quantified Medicine 89
MedaCheck 89
Care Management Workflow Framework 89
Health Saathi 90
MedSync-Rx 90
RXShare 90
TrackMyStack 91
OATBook 91
Pocket Pill 91
Healthera 91
OpiSafe 91
CuePath 92
Medicyne 92
Plan-it Med 92
eCareCoordinator Platform 93
Care4today Mobile Health Manager 93
AiCure 93
Nightingale 93

List of Tables
Summary Table: Global Market for Medication Adherence, by Region, Through 2021 ($ Millions) ........ 10
Table 1 Global Prevalence of Angina Pectoris and Stroke (Survivors), Through 2030 (Thousands) .......... 16
Table 2 Global Incidence of Congestive Heart Failure and Stroke, Through 2030 (Thousands)... 18
Table 3 Global Incidence of Hypertension, by Patient Group, 2015 (% of Total Patients) ........... 19
Table 4 Global Symptomatic Prevalence of Key Musculoskeletal Disorders, Through 2021 (Thousands) 22
Table 5 Global Deaths by Various Musculoskeletal Disorders, Through 2030 (No.) ....... 23
Table 6 Global Deaths from Digestive Diseases, by Region, Through 2021 (Thousands)  24
Table 7 Global Prevalence of Breast Cancer, by Region, Through 2021 (Millions) .......... 31
Table 8 Global Epidemiology of Colon Cancer, by Region, Through 2030 (Thousands) ... 33
Table 9 Global Deaths, by Various Cancer Types, Through 2030 (Thousands) ... 34
Table 10 Global Deaths, by Various Cancer Types, 2015 (% of Total Deaths Due to Cancer) ...... 35
Table 11 Global Diabetes Types (% of Total Diabetes) ............ 40
Table 12 Global Prevalence of Diabetes, by Type, Through 2040 (Millions) ..... 42
Table 13 BMI Calculation ....... 43
Table 14 BMI Categories Based on Increasing Health Risks ...... 44
Table 15 Trends in Obesity Composition of the World’s Population, Through 2020 (Millions) ... 45
Table 16 U.S. Obesity and Severe Obesity vs. General Population, Through 2021 (Millions) ...... 47
Table 17 Automated Medication Dispensing Cabinets  59
Table 18 Smart Pill Dispensers, Pillboxes and Organizers ......... 61
Table 19 Medication Tracking Devices and Apps ......... 63
Table 20 Pill Organizer and Reminder Systems............ 65
Table 21 Smart Pill Cap and Bottle Systems .... 66
Table 22 Specialized Medication Adherence Devices .. 68
Table 23 Smart Pills for Patient Monitoring .... 69
Table 24 Smart Pills for Oral Drug Delivery ..... 72
Table 25 Other Medication Adherence Solutions ........ 73
Table 26 Health and Medication Reminder Apps ........ 83
Table 27 Personalized Medication Adherence and Text Messaging Apps.......... 85
Table 28 Health and Medication Monitoring Apps ...... 90
Table 29 Cloud-based Adherence Solutions and Databases ..... 92
Table 30 Health and Medication Adherence Apps ...... 94
Table 31 Other Medication Adherence Apps .. 96
Table 32 Global Market for Medication Adherence, by Region, Through 2021 ($ Millions) ...... 103
Table 33 Global Market for Medication Adherence Systems, by Segment, Through 2021 ($ Millions).. 104
Table 34 Global Market for Medication Adherence, by Disease, Through 2021 ($ Millions) ..... 105
Table 35 Global Market for Medication Adherence, by Leading Companies, 2016 ($ Millions/%) ......... 111
Table 36 Recent Key Strategic Deals in the Medication Adherence Market .... 116
Table 37 Differences in Regulatory Approval in The U.S. and Europe . 124
Table 38 Trends in Per Capita Real GDP Growth, by Region, 2012–2015 (Annual Average Percentage Change) ........ 138
Table 39 List of Acronyms ... 172   

List of Figures
Summary Figure: Global Market for Medication Adherence, by Region, 2015-2021 ($ Millions) ........... 11
Figure 1 Global Prevalence of Angina Pectoris and Stroke (Survivors), 2004–2030 (Thousands)  17
Figure 2 Global Incidence of Congestive Heart Failure and Stroke, 2004–2030 (Thousands) ...... 18
Figure 3 Global Incidence of Hypertension, by Patient Group, 2015 (% of Total Patients) .......... 20
Figure 4 Global Symptomatic Prevalence of Key Musculoskeletal Disorders, by Region, 2015 (Thousands) ........... 22
Figure 5 Global Deaths by Various Musculoskeletal Disorders, 2015 (% of Total Deaths due to Musculoskeletal Disorders) .... 23
Figure 6 Global Deaths from Digestive Diseases, by Region, 2015–2021 (Thousands) ... 25
Figure 7 Global Prevalence of Breast Cancer, by Region, 2015-2021 (Millions) .. 31
Figure 8 Global Epidemiology of Colon Cancer, by Region, 2000–2030 (Thousands) ..... 33
Figure 9 Global Deaths, by Various Cancer Types, 2000–2030 (Thousands) ...... 35
Figure 10 Global Deaths, by Various Cancer Types, 2015 (% of Total Deaths Due to Cancer) ..... 36
Figure 11 Global Diabetes Types (% of Total Diabetes) ........... 40
Figure 12 Global Prevalence of Diabetes, by Type, 2015–2040 (Millions) .......... 42
Figure 13 Trends in Obesity Composition of the World’s Population, 2012–2020 (Millions) ...... 46
Figure 14 U.S. Obesity and Severe Obesity vs. General Population, 2015–2021 (Millions) ......... 47
Figure 15 Global Market for Medication Adherence, by Region, 2015–2021 ($ Millions) ......... 103
Figure 16 Global Market for Medication Adherence Systems, by Segment, 2015–2021 ($ Millions) ..... 104
Figure 17 Global Market for Medication Adherence, by Disease, 2015–2021 ($ Millions) ........ 106
Figure 18 Global Market for Medication Adherence, By Leading Companies, 2016 (%) ............ 112
Figure 19 Trends in Per Capita Real GDP Growth, by Region, 2012-2015 (Annual Average Percentage Change) ...... 138

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