CNS Cluster Addiction Drug Development Pipeline Review, 2017

 Published On: May, 2017 |    No of Pages: 150 |  Published By: GBI Research | Format: PDF
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Summary

The central nervous system (CNS) addiction cluster report provides an overview of the CNS Clusters pipeline landscape. The report provides comprehensive information on the therapeutics under development, and key players involved in therapeutic development for Alcohol Addiction, Drug Addiction, Nicotine Addiction, Opium (Opioid) Addiction and features dormant and discontinued projects.

Alcohol addiction refers to a psychological and physical dependency on alcohol. Symptoms include decreased involvement in extracurricular activities, depression, restlessness, inability to control drinking and violent behavior. Drug addiction, also called substance dependence or chemical dependency, is a disease that is characterized by a destructive pattern of drug abuse that leads to significant problems involving tolerance to or withdrawal from the substance. Nicotine addiction also called tobacco dependence is an addiction to tobacco products caused by the drug nicotine. Finally, opioid addiction develops after using opioids regularly for a period of time. Prolonged use of opiates can lead to nerve damage within the brain that causes cells to stop producing endogenous opiates (natural painkillers known as endorphins).

The size of these pipelines ranges from 19 in nicotine addiction to 67 in drug addiction, with a substantial degree of overlap between these indications in terms of the key players and the types of molecular target which are being studied. The mu and kappa-opioid receptors are the dominant molecular target across alcohol, drug and opioid addiction, and other neurotransmitter receptors such as the cannabinoid and dopamine receptors are common molecular targets across the three.

Scope

- Which companies are the most active within the pipeline for addiction therapeutics?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in the field of addiction therapeutics?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration
Table of Contents
GBI Research Report Guidance 2
Executive Summary 3
Table of Contents 4
List of Tables 6
List of Figures 9
Introduction 10
CNS Cluster Addiction Report Coverage 10
Alcohol Addiction Overview 10
Drug Addiction Overview 10
Nicotine Addiction Overview 10
Opium (Opioid) Addiction Overview 10
Therapeutics Development 11
Alcohol Addiction 11
Drug Addiction 17
Nicotine Addiction 25
Opium (Opioid) Addiction 28
Therapeutics Assessment 34
Alcohol Addiction 34
Drug Addiction 41
Nicotine Addiction 50
Opium (Opioid) Addiction 56
Companies Involved in Therapeutics Development 65
Alcohol Addiction 65
Drug Addiction 78
Nicotine Addiction 90
Opium (Opioid) Addiction 94
Dormant Projects 104
Alcohol Addiction 104
Drug Addiction 106
Nicotine Addiction 108
Opium (Opioid) Addiction 109
Discontinued Products 110
Alcohol Addiction 110
Drug Addiction 110
Nicotine Addiction 110
Opium (Opioid) Addiction 111
Product Development Milestones 112
Alcohol Addiction 112
Drug Addiction 123
Nicotine Addiction 134
Opium (Opioid) Addiction 137
Appendix 149
Methodology 149
Coverage 149
Secondary Research 149
Primary Research 149
Expert Panel Validation 149
Contact Us 149
Disclaimer 150

List of Tables
Number of Products under Development for Alcohol Addiction 11
Number of Products under Development by Companies, Alcohol Addiction 13
Number of Products under Development by Universities/Institutes, Alcohol Addiction 14
Products under Development by Companies, Alcohol Addiction 15
Products under Development by Universities/Institutes, Alcohol Addiction 16
Number of Products under Development for Drug Addiction 17
Number of Products under Development by Companies, Drug Addiction 19
Number of Products under Development by Universities/Institutes, Drug Addiction 21
Products under Development by Companies, Drug Addiction 22
Products under Development by Universities/Institutes, Drug Addiction 24
Number of Products under Development for Nicotine Addiction 25
Number of Products under Development by Companies, Nicotine Addiction 26
Number of Products under Development by Universities/Institutes, Nicotine Addiction 27
Products under Development by Companies, Nicotine Addiction 27
Products under Development by Universities/Institutes, Nicotine Addiction 28
Number of Products under Development for Opium (Opioid) Addiction 29
Number of Products under Development by Companies, Opium (Opioid) Addiction 30
Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction 31
Products under Development by Companies, Opium (Opioid) Addiction 32
Products under Development by Universities/Institutes, Opium (Opioid) Addiction 33
Number of Products by Stage and Target, Alcohol Addiction 35
Number of Products by Stage and Mechanism of Action, Alcohol Addiction 37
Number of Products by Stage and Route of Administration, Alcohol Addiction 39
Number of Products by Stage and Molecule Type, Alcohol Addiction 41
Number of Products by Stage and Target, Drug Addiction 43
Number of Products by Stage and Mechanism of Action, Drug Addiction 45
Number of Products by Stage and Route of Administration, Drug Addiction 48
Number of Products by Stage and Molecule Type, Drug Addiction 50
Number of Products by Stage and Target, Nicotine Addiction 51
Number of Products by Stage and Mechanism of Action, Nicotine Addiction 53
Number of Products by Stage and Route of Administration, Nicotine Addiction 54
Number of Products by Stage and Molecule Type, Nicotine Addiction 56
Number of Products by Stage and Target, Opium (Opioid) Addiction 58
Number of Products by Stage and Mechanism of Action, Opium (Opioid) Addiction 60
Number of Products by Stage and Route of Administration, Opium (Opioid) Addiction 62
Number of Products by Stage and Molecule Type, Opium (Opioid) Addiction 64
Alcohol Addiction Pipeline by AbbVie Inc 65
Alcohol Addiction Pipeline by Addex Therapeutics Ltd 65
Alcohol Addiction Pipeline by Adial Pharmaceuticals LLC 66
Alcohol Addiction Pipeline by Astraea Therapeutics LLC 66
Alcohol Addiction Pipeline by BioCorRx Inc 67
Alcohol Addiction Pipeline by Bionex Pharmaceuticals LLC 67
Alcohol Addiction Pipeline by Bioprojet SCR 68
Alcohol Addiction Pipeline by Cerecor Inc 68
Alcohol Addiction Pipeline by Chronos Therapeutics Ltd 69
Alcohol Addiction Pipeline by Corcept Therapeutics Inc 69
Alcohol Addiction Pipeline by Curemark LLC 70
Alcohol Addiction Pipeline by Eli Lilly and Company 70
Alcohol Addiction Pipeline by Ethypharm SA 71
Alcohol Addiction Pipeline by Euthymics Bioscience Inc 72
Alcohol Addiction Pipeline by H. Lundbeck A/S 72
Alcohol Addiction Pipeline by Heptares Therapeutics Ltd 72
Alcohol Addiction Pipeline by Indivior Plc 73
Alcohol Addiction Pipeline by Kinnov Therapeutics SAS 73
Alcohol Addiction Pipeline by Kyorin Pharmaceutical Co Ltd 74
Alcohol Addiction Pipeline by Lohocla Research Corp 74
Alcohol Addiction Pipeline by Omeros Corp 75
Alcohol Addiction Pipeline by Pfizer Inc 75
Alcohol Addiction Pipeline by Savant HWP Inc 75
Alcohol Addiction Pipeline by SK Biopharmaceuticals Co Ltd 76
Alcohol Addiction Pipeline by Tonix Pharmaceuticals Holding Corp 76
Alcohol Addiction Pipeline by VM Discovery Inc 77
Alcohol Addiction Pipeline by XenoPort Inc 77
Alcohol Addiction Pipeline by Zynerba Pharmaceuticals Inc 78
Drug Addiction Pipeline by Addex Therapeutics Ltd 78
Drug Addiction Pipeline by Aelis Farma SAS 79
Drug Addiction Pipeline by Aphios Corp 79
Drug Addiction Pipeline by Astraea Therapeutics LLC 79
Drug Addiction Pipeline by BioCorRx Inc 80
Drug Addiction Pipeline by Cerecor Inc 80
Drug Addiction Pipeline by Chiesi Farmaceutici SpA 81
Drug Addiction Pipeline by Curemark LLC 81
Drug Addiction Pipeline by Embera NeuroTherapeutics Inc 82
Drug Addiction Pipeline by F. Hoffmann-La Roche Ltd 82
Drug Addiction Pipeline by Foresee Pharmaceuticals LLC 83
Drug Addiction Pipeline by Heptares Therapeutics Ltd 83
Drug Addiction Pipeline by Immunovaccine Inc 84
Drug Addiction Pipeline by Indivior Plc 84
Drug Addiction Pipeline by InterveXion Therapeutics LLC 84
Drug Addiction Pipeline by Intra-Cellular Therapies Inc 85
Drug Addiction Pipeline by Kyorin Pharmaceutical Co Ltd 85
Drug Addiction Pipeline by Kyowa Hakko Kirin Co Ltd 86
Drug Addiction Pipeline by MedRev Pharma 86
Drug Addiction Pipeline by NLS Pharma Group 86
Drug Addiction Pipeline by Omeros Corp 87
Drug Addiction Pipeline by Opiant Pharmaceuticals Inc 87
Drug Addiction Pipeline by Orexigen Therapeutics Inc 88
Drug Addiction Pipeline by P2D Bioscience 88
Drug Addiction Pipeline by Saniona AB 89
Drug Addiction Pipeline by Savant HWP Inc 89
Drug Addiction Pipeline by Stada Arzneimittel AG 89
Drug Addiction Pipeline by Teva Pharmaceutical Industries Ltd 90
Drug Addiction Pipeline by Zynerba Pharmaceuticals Inc 90
Nicotine Addiction Pipeline by Addex Therapeutics Ltd 91
Nicotine Addiction Pipeline by Astraea Therapeutics LLC 91
Nicotine Addiction Pipeline by C4X Discovery Holdings PLC 91
Nicotine Addiction Pipeline by Chronos Therapeutics Ltd 92
Nicotine Addiction Pipeline by CV Sciences Inc 92
Nicotine Addiction Pipeline by Hager Biosciences LLC 93
Nicotine Addiction Pipeline by Heptares Therapeutics Ltd 93
Nicotine Addiction Pipeline by Omeros Corp 93
Nicotine Addiction Pipeline by Savant HWP Inc 94
Opium (Opioid) Addiction Pipeline by Alkermes Plc 94
Opium (Opioid) Addiction Pipeline by Aoxing Pharmaceutical Company Inc 95
Opium (Opioid) Addiction Pipeline by Aquilus Pharmaceuticals Inc 95
Opium (Opioid) Addiction Pipeline by BioCorRx Inc 95
Opium (Opioid) Addiction Pipeline by BioDelivery Sciences International Inc 96
Opium (Opioid) Addiction Pipeline by Camurus AB 96
Opium (Opioid) Addiction Pipeline by Foresee Pharmaceuticals LLC 97
Opium (Opioid) Addiction Pipeline by Heron Therapeutics Inc 97
Opium (Opioid) Addiction Pipeline by Indivior Plc 98
Opium (Opioid) Addiction Pipeline by INSYS Therapeutics Inc 99
Opium (Opioid) Addiction Pipeline by Omeros Corp 99
Opium (Opioid) Addiction Pipeline by Opiant Pharmaceuticals Inc 100
Opium (Opioid) Addiction Pipeline by Orexigen Therapeutics Inc 100
Opium (Opioid) Addiction Pipeline by Orexo AB 101
Opium (Opioid) Addiction Pipeline by Pfizer Inc 101
Opium (Opioid) Addiction Pipeline by Relmada Therapeutics Inc 101
Opium (Opioid) Addiction Pipeline by Savant HWP Inc 102
Opium (Opioid) Addiction Pipeline by Teva Pharmaceutical Industries Ltd 102
Opium (Opioid) Addiction Pipeline by Titan Pharmaceuticals Inc 103
Opium (Opioid) Addiction Pipeline by Zynerba Pharmaceuticals Inc 103
Alcohol Addiction Dormant Projects 104
Drug Addiction Dormant Projects 106
Nicotine Addiction Dormant Projects 108
Opium (Opioid) Addiction Dormant Projects 109
Alcohol Addiction Discontinued Products 110
Drug Addiction Discontinued Products 110
Nicotine Addiction Discontinued Products 110
Opium (Opioid) Addiction Discontinued Products 111

List of Figures
Number of Products under Development for Alcohol Addiction 11
Number of Products under Development by Companies, Alcohol Addiction 12
Number of Products under Development by Universities/Institutes, Alcohol Addiction 14
Number of Products under Development for Drug Addiction 17
Number of Products under Development by Companies, Drug Addiction 18
Number of Products under Development by Universities/Institutes, Drug Addiction 20
Number of Products under Development for Nicotine Addiction 25
Number of Products under Development by Companies, Nicotine Addiction 26
Number of Products under Development for Opium (Opioid) Addiction 28
Number of Products under Development by Companies, Opium (Opioid) Addiction 29
Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction 31
Number of Products by Top 10 Targets, Alcohol Addiction 34
Number of Products by Stage and Top 10 Targets, Alcohol Addiction 34
Number of Products by Top 10 Mechanism of Actions, Alcohol Addiction 36
Number of Products by Stage and Top 10 Mechanism of Actions, Alcohol Addiction 36
Number of Products by Routes of Administration, Alcohol Addiction 38
Number of Products by Stage and Routes of Administration, Alcohol Addiction 38
Number of Products by Molecule Types, Alcohol Addiction 39
Number of Products by Stage and Molecule Types, Alcohol Addiction 40
Number of Products by Top 10 Targets, Drug Addiction 41
Number of Products by Stage and Top 10 Targets, Drug Addiction 42
Number of Products by Top 10 Mechanism of Actions, Drug Addiction 44
Number of Products by Stage and Top 10 Mechanism of Actions, Drug Addiction 44
Number of Products by Routes of Administration, Drug Addiction 47
Number of Products by Stage and Routes of Administration, Drug Addiction 47
Number of Products by Molecule Types, Drug Addiction 48
Number of Products by Stage and Molecule Types, Drug Addiction 49
Number of Products by Top 10 Targets, Nicotine Addiction 50
Number of Products by Stage and Top 10 Targets, Nicotine Addiction 51
Number of Products by Top 10 Mechanism of Actions, Nicotine Addiction 52
Number of Products by Stage and Top 10 Mechanism of Actions, Nicotine Addiction 52
Number of Products by Stage and Routes of Administration, Nicotine Addiction 54
Number of Products by Molecule Types, Nicotine Addiction 55
Number of Products by Stage and Molecule Types, Nicotine Addiction 55
Number of Products by Top 10 Targets, Opium (Opioid) Addiction 56
Number of Products by Stage and Top 10 Targets, Opium (Opioid) Addiction 57
Number of Products by Top 10 Mechanism of Actions, Opium (Opioid) Addiction 59
Number of Products by Stage and Top 10 Mechanism of Actions, Opium (Opioid) Addiction 59
Number of Products by Routes of Administration, Opium (Opioid) Addiction 61
Number of Products by Stage and Routes of Administration, Opium (Opioid) Addiction 61
Number of Products by Molecule Types, Opium (Opioid) Addiction 63
Number of Products by Stage and Molecule Types, Opium (Opioid) Addiction 63

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