RNAi Drug Delivery: Technologies and Global Markets

Abstract
Report Scope:

This research report categorizes the market for nucleic acid drugs by type. The major product segments are conjugated and encapsulated. The non-viral vectors used for encapsulation are divided into polymers, lipids and others (e.g., inorganic material, hybrid systems). The market is also segmented based on the molecule types, delivery modes and therapeutic areas. It is divided by application types into therapeutic applications and research-based applications. The markets in North America, Europe, the Asia-Pacific region and Rest of the World (RoW) are covered.

Report Includes:

- 24 data tables and 45 additional tables
- An up-to-date overview and industry analysis of the global markets for RNA interference (RNAi) drug delivery technologies
- Analyses of the global market trends, with historic market revenue (sales figures) from 2020 to 2022, estimates for 2023, and projections of compound annual growth rates (CAGRs) through 2028
- Estimation of the actual market size and revenue forecast for the RNAi drug delivery technologies market, and corresponding market share analysis based on type of RNAi, therapeutic area, and region
- Discussion of major growth drivers, industry-specific challenges, regulatory aspects, and technology advancement that will shape the market for RNAi drug delivery technologies as a basis for projecting demand in the next few years (2023-2028)
- Review of key patent grants and patent applications on RNAi drug delivery markets, and emerging technologies and new developments within the marketplace
- Latest information on the mergers and acquisition deals, partnerships, agreements, collaborations, and other strategic alliances within the marketplace
- Insight into the recent industry structure, competitive aspects of each product segments, increasing investment on R&D activities, market growth strategies, and company revenue share analysis
- A look at commercial opportunities in the RNAi research tools and reagents, recent progress and future opportunities for RNAi therapeutics in various disease classifications, clinical trial applications, and potential markets for future developments
- Identification of the major stakeholders and analysis of the competitive landscape based on recent developments, segmental revenues, and operational integration
- Descriptive company profiles of the leading global players of the industry, including Alnylam Pharmaceuticals, Benitec Biopharma, Ionis Phamaceutical, Novo Nordisk and Sirnaomics Inc.

Content
Table of Contents

Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing the Study
Scope of Report
What's New in This Update?
Research Methodology
Geographic Breakdown
Chapter 2 Summary and Highlights
Market Outlook
Chapter 3 Market Overview
Introduction
History of Nucleic Acid Drugs
Antisense Oligonucleotides
RNA
Drug Delivery System
Nucleic Acid Drugs
Inhibition Type
Antisense Oligonucleotide
Regulations
Pre-Clinical INDA
COVID-19 Impact Analysis on the RNAi Drug Delivery Markets
Positive Impact of COVID-19
Negative Effect of COVID-19
Chapter 4 Market Dynamics
Market Drivers
Approved RNAi Drugs
Venture Funding Increased in RNAi Drugs
RNAi Drugs Designated as Orphan Drugs
New Nanoparticle Technologies for Drug Delivery Systems
Market Restraints
High Drug Costs
Lack of Awareness Regarding Rare Diseases
Clustered Regularly Interspaced Short Palindromic Repeats Technology Application Growing
Market Opportunities
Application in Cancer Treatment
Infectious Disease and RNAi Drugs
Chapter 5 Nucleic Acid Drug Delivery Technology Market by Type
Encapsulation
Viral Vector-Based
Non-Viral Vector-Based Delivery System
Conjugates
Chapter 6 Market Breakdown by Application
Drug Development and Discovery
Process of RNA-Based Drug Discovery
Design of RNAi Drugs
Sequence Optimization
Chemical Modification
Targeted Delivery
Therapeutic Application
Chapter 7 Market Breakdown by Route of Administration
Chapter 8 Market Breakdown by Molecules
Small Interfering Ribonucleic Acid
Antisense Oligonucleotide
Fomivirsen (Vitravene)
Mipomersen
Nusinersen (Spinraza)
Inotersen (Tegsedi)
Eteplirsen (Exondys 51)
Golodirsen (Vyondys 53)
Milasen: A Unique Personalized Medicine
Messenger RNA
Others
Aptamers
Micro RNA
Chapter 9 Market Breakdown by Therapeutic Area
Oncology
Rare and Genetic Diseases
Central Nervous System
Respiratory
Other Disease
Chapter 10 Market Breakdown by Region
North America
Europe
Asia-Pacific
Japan
South Korea
China
India
Australia
Rest of the World
Chapter 11 Environmental, Social and Governance in the Biotechnology Sector
Key Environmental, Social and Governance Issues in the Biotechnology Industry
Biotechnology Industry Environmental, Social and Governance Performance Analysis
Environmental Performance
Social Performance
Governance Performance
Consumer Perspective on ESG in Biotechnology
Case Study
Concluding Remarks from BCC Research
Chapter 12 Emerging Technologies and Developments
Drug Delivery to Lungs
Nanotechnology
Use of Artificial Intelligence and Machine Learning
Chapter 13 Clinical Trial and Patent Analysis
Clinical Trials Analysis
Patent Analysis
Chapter 14 Mergers and Acquisitions and Funding Outlook
Start-Up Funding in Nucleic Acid Delivery Technology
Chapter 15 Competitive Intelligence
Chapter 16 Company Profiles
ALNYLAM PHARMACEUTICALS INC.
ARCTURUS THERAPEUTICS INC.
ARBUTUS BIOPHARMA CORP.
ARROWHEAD PHARMACEUTICALS INC.
BENITEC BIOPHARMA
CELLECTA INC.
ELEVEN THERAPEUTICS
GENEVANT SCIENCES CORP.
IONIS PHARMACEUTICALS INC.
MIRIMUS, INC.
NOVO NORDISK
NANODE THERAPEUTICS INC.
OLIX PHARMACEUTICALS
PHIO PHARMACEUTICALS CORP.
SILENCE THERAPEUTICS PLC
SIRNAOMICS INC.
SOMAGENICS, INC.

List of Tables
Summary Table : Global Market for Nucleic Acid Drug Delivery, by Type, Through 2028
Table 1 : Challenges for the Delivery of Nucleic Acid Drugs
Table 2 : Differences Between Small Molecule Drugs and Biological Drugs
Table 3 : Nucleic Acid Drug Classification
Table 4 : Nucleic Acid Drug Types
Table 5 : siRNA Therapeutics for SARS-CoV-2, SARS-CoV-1 and MERS-CoV, 2021
Table 6 : Orphan Drug Incentives in Various Countries
Table 7 : Direct Methods of Insertion into the Cell
Table 8 : Advantages and Disadvantages of Various Kinds of Drug Delivery Systems
Table 9 : Advantages and Disadvantages of Viral Vectors
Table 10 : Global Market for Nucleic Acid Drug Delivery, by Encapsulation Material Type, Through 2028
Table 11 : Lipid Nanoparticles and Their Functions
Table 12 : Lipid Nanoparticle Types and Their Advantages and Disadvantages
Table 13 : Comparison of Polymeric Vectors and Lipid-Based Vectors
Table 14 : Polymer Types for Nucleic Acid Drug Delivery and Their Properties
Table 15 : Global Market for Nucleic Acid Drug Delivery, by Application, Through 2028
Table 16 : Approved Nucleic Acid Drugs, upto June 2023
Table 17 : Routes of Administration for Nucleic Acid Drugs
Table 18 : Global Market for Nucleic Acid Drug Delivery, by Route of Aministration, Through 2028
Table 19 : Characteristics of Different Molecule Types for Nucleic Acid Drug
Table 20 : Global Market for Nucleic Acid Drug Delivery, by Molecule Type, Through 2028
Table 21 : Comparison ASO Versus siRNA
Table 22 : Various mRNA Drugs Under Clinical Trials, June 2023
Table 23 : Comaprision of miRNA and siRNA
Table 24 : Global Market for Nucleic Acid Drug Delivery, by Therapeutic Area, Through 2028
Table 25 : Global Market for Nucleic Acid Drug Delivery, by Region, Through 2028
Table 26 : North American Market for Nucleic Acid Drug Delivery, by Type, Through 2028
Table 27 : North American Market for Non-Viral Vector Nucleic Acid Drug Delivery, by Type, Through 2028
Table 28 : U.S. Biotech Private Rounds for Nucleic Acid-Based, June 2022
Table 29 : European Market for Nucleic Acid Drug Delivery, by Type, Through 2028
Table 30 : European Market for Non-Viral Vector Nucleic Acid Drug Delivery, by Type, Through 2028
Table 31 : Asia-Pacific Market for Nucleic Acid Drug Delivery, by Type, Through 2028
Table 32 : Asia-Pacific Market for Non-Viral Vector Nucleic Acid Drug Delivery, by Type, Through 2028
Table 33 : Rest of the World Market for Nucleic Acid Drug Delivery, by Type, Through 2028
Table 34 : Rest of the World Market for Non-Viral Vector Nucleic Acid Drug Delivery, by Type, Through 2028
Table 35 : Alnylam ESG initiatives
Table 36 : Patents Issued on Nucleic Acid Drug Deivery, 2000-2020
Table 37 : Collaboration in Nucleic Acid Drug Delivery Market, 2021-2023
Table 38 : Start-Up Funding in the Nucleic Acid Drug Delivery Industry, January 2022 and March 2023
Table 39 : Collaborations in the Nucleic Acid Drug Delivery Market, 2021-2023
Table 40 : Clinical Trials and Approvals in the Nucliec Acid Drug Delivery Market, 2021-2023
Table 41 : Other Strategic Developments in Nucleic Acid Drug Delivery Market, 2021-2023
Table 42 : Alnylam Pharmaceuticals Inc.: Annual Revenue, 2022
Table 43 : Alnylam Pharmaceuticals: Pipeline Products
Table 44 : Alnylam Pharmaceuticals: Product Portfolio
Table 45 : Alnylam Pharmaceuticals: Recent Developments, 2021-2023
Table 46 : Arcturus Therapeutics Inc.: Annual Revenue, 2022
Table 47 : Arcturus Therapeutics: Pipeline Products
Table 48 : Arcturus Therapeutics: Recent Developments, 2021-2023
Table 49 : Arbutus Biopharma Corp.: Collaborations, 2021-2023
Table 50 : Arbutus Biopharma Corp.: Annual Revenue, 2022
Table 51 : Arbutus Biopharma Corp.: Recent Developments, 2021-2023
Table 52 : Pipeline of Arrowhead Pharmaceuticals
Table 53 : Benitec Biopharma: Annual Revenue, 2022
Table 54 : Eleven Therapeutics: Recent Developments, 2022
Table 55 : Genevant: Recent Developments, 2021 and 2022
Table 56 : Ionis Phamaceutical Inc.: Annual Revenue, 2022
Table 57 : Pipeline Products of Ionis Pharmaceuticals
Table 58 : Ionis Pharmaceuticals Inc.: Recent Developments, 2023
Table 59 : Mirimus Inc.: Recent Developments, 2021 and 2022
Table 60 : Novo Nordisk: Annual Revenue, 2022
Table 61 : Pipeline Products of Novo Nordisk
Table 62 : Pipeline Products of Nanode Therapeutics
Table 63 : Olix Pharmaceuticals: Recent Developments, 2021-2023
Table 64 : Slience Therapeutics: Annual Revenue, 2022
Table 65 : Pipeline of Silence Therapeutics
Table 66 : Silence Therapeutics: Recent Developments, 2023
Table 67 : Pipeline of Sirnaomics Inc.
Table 68 : Sirnaomics Inc.: Recent Developments, 2021-2023