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RNAi Technologies and Global Markets

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Published Date: Oct, 2013
Format: PDF
No of Pages: 134
 
 
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  • Abstract
  • Table of Contents

REPORT HIGHLIGHTS

This report provides:

-An overview of the global market for RNAi technologies which are used in the areas of drug delivery, therapeutics, and diagnostics.
-Analyses of global market trends, with data from 2011 and 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) for the period 2013 to 2018.
-A breakdown of the technologies: RNAi for drug delivery (by nanoparticle delivery, nucleic acid delivery, aptamer delivery); RNAi for drug discovery and therapeutics (by diseases); RNAi for disease diagnostics and biomarker development (by diseases); and -RNAi for reagents, research tools, and other applications (by application).
-Examination of significant deals in the RNAi technologies sector during the last decade.
-Comprehensive company profiles of major players in the market.

INTRODUCTION

STUDY GOALS AND OBJECTIVES


This BCC Research report, RNAi: Technologies and Global Markets, provides an overview of the current state of the RNA interference (RNAi) market, focusing specifically on RNAi research tools and reagents, drug discovery and diagnostics. It describes the available technologies and the major players currently working in the market, as well as detailed analysis of the competitive environments, including new potential trends in research and product development. This report also includes information regarding trends and obstacles affecting this market and its different sectors.

REASONS FOR DOING THE STUDY

Since its discovery, RNAi has become ubiquitous in biomedical research. RNAi provides benefits to the scientific research community and also has huge potential in therapeutics and diagnostics. The RNAi industry as a whole, however, has faced many difficulties in recent years. As the industry starts to warm up again in 2013, an updated comprehensive technology and business description is needed to better understand the field.

More therapeutics and diagnostics companies recognize the potential of RNAi, and thus they must understand the opportunities and challenges it presents. Insiders from both pharmaceutical companies and the RNAi industry will benefit from this study.

The RNAi market is part of general RNA market, but it has its own characteristics and unique competitive landscape. This report specifically covers RNAi, which is a very important gene-silencing mechanism. Researchers around the world use RNAi as a tool; moreover, pharmaceutical companies and agriculture companies have started to realize its potential in medicine and biotechnology.

This report highlights the main segments within the RNAi market:

Research tools and reagents.
Drug development.
Diagnostics.
Agriculture.

RNAi drug delivery is discussed in one independent chapter due to its importance for drug development. Significant events and deals, as well as future trends and obstacles in the industry, are also discussed.

SCOPE OF REPORT

This report is a business tool that can help existing and potential market players to properly evaluate the commercial opportunities in the RNAi research tools and reagents, drug development, diagnostic and agriculture markets. The geographic scope is global. The RNAi market is complex, consisting of a number of different segments. Each segment is affected differently by technological and regulatory developments. This report identifies the main factors affecting each segment and forecasts market growth, future trends and product development in every major market segment.

METHODOLOGY AND INFORMATION SOURCES

Both primary and secondary research methodologies were used to prepare this study. Initially, a comprehensive and exhaustive search of the literature on drug discovery and already-marketed products was conducted. These secondary sources included drug discovery and science-related journals, textbooks, press releases, marketing literatures, other product and promotional literature, annual reports, security analyst reports, and company websites. A patent search and analysis was also conducted.

In the second phase, a series of semi-structured interviews were conducted with company representatives, bench scientists, marketing representatives, and other personnel at biotechnology and pharmaceutical companies. Other sources included academics, technology, and consulting companies. Subsequent analysis of the documents and interview notes was iterative.

INTENDED AUDIENCE

This report is intended for business development professionals, entrepreneurs, and other investors who need to fully understand and properly evaluate each segment of the market for RNAi research tools reagents, drug developments, diagnostics and agriculture. It provides insights into the market position of major companies and presents new opportunities overlooked or less known to the business communities. 

Chapter- 1: INTRODUCTION - Complimentary 3 $0
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
METHODOLOGY AND INFORMATION SOURCES
INTENDED AUDIENCE
ANALYST CREDENTIALS
RELATED REPORTS
BCC ONLINE SERVICES
DISCLAIMER

Chapter- 2: SUMMARY 2 $250
Table Summary : GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, THROUGH 2018
Figure Summary : GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, 2011-2018

Chapter- 3: INTRODUCTION TO RNAI TECHNOLOGIES 21 $1281
OVERVIEW
RNAI DISCOVERY
RNAI GENE-SILENCING MECHANISM
MICRORNA
RNAI APPLICATIONS
RNAI MARKET OVERVIEW
INTELLECTUAL PROPERTY IN THE RNAI MARKETPLACE
RNAI MARKETPLACE FUTURE

Chapter- 4: RNAI RESEARCH TOOL AND REAGENT MARKET 13 $793
OVERVIEW
THERMO FISHER: RNAI RESEARCH TOOLS AND REAGENTS
LIFE TECHNOLOGIES: RNAI RESEARCH TOOLS AND REAGENTS
SIGMA-ALDRICH: RNAI RESEARCH TOOLS AND REAGENTS
OTHER SIGNIFICANT PLAYERS IN THE MARKET
OPPORTUNITIES FOR MIDDLE- AND SMALL-SIZE COMPANIES
INDUSTRY ANALYSIS
SUMMARY OF RNAI RESEARCH TOOLS AND REAGENTS MARKET

Chapter- 5: RNAI DRUG DELIVERY 28 $1708
OVERVIEW
BARRIERS FOR RNAI DRUG DELIVERY
GOALS FOR RNAI DRUG DELIVERY
SIRNA DELIVERY ASSAY SYSTEMS
RNAI DRUG DELIVERY STRATEGIES
METHODS FOR RNAI DRUG DELIVERY
PHYSICAL RNAI DELIVERY
VECTOR-BASED RNAI DELIVERY
CARRIER-BASED DELIVERY
RNA MODIFICATIONS
RNAI DELIVERY SYSTEM IN CANCER RESEARCH
RNAI DELIVERY METHODS FOR INDIVIDUAL ORGANS
NOTABLE PROPRIETARY DELIVERY PLATFORMS
SUMMARY

Chapter- 6: RNAI DRUG DEVELOPMENT 26 $1586
OVERVIEW
RNA-BASED THERAPIES
ANTISENSE RNA THERAPY
RNAI DRUG DISCOVERY AND THERAPEUTICS
RNAI DRUG DISCOVERY STRATEGIES
RNAI THERAPEUTIC DESIGN
RNAI-BASED THERAPEUTICS FOR VARIOUS DISEASES
NOTABLE RNAI DRUG DISCOVERY COMPANIES
ANTISENSE VERSUS RNAI
RNAI DRUG DISCOVERY MARKET SUMMARY

Chapter- 7: RNAI DIAGNOSTICS 14 $854
INTRODUCTION
MICRORNA IN HUMAN CANCER DIAGNOSTICS
MICRORNAS AS PROGNOSTIC AND PREDICTIVE BIOMARKERS
CHALLENGES ASSOCIATED WITH MICRORNA AS A BIOMARKER
MICRORNA DIAGNOSTICS MARKET DRIVERS
SIGNIFICANT PLAYERS IN THE MICRORNA DIAGNOSTIC MARKET
SUMMARY AND FUTURE PERSPECTIVES

Chapter- 8: RNAI IN AGRICULTURE 5 $305
INTRODUCTION
RNAI-BASED BIOTECHNOLOGY SAFETY CONCERNS
RNAI APPLICATION IN CROPS
RNAI APPLICATION IN VIRUS AND PEST CONTROL
RNAI APPLICATION IN AQUACULTURE
SUMMARY AND FUTURE PERSPECTIVE

Chapter- 9: COMPANY PROFILES 8 $488
BIG PHARMA COMPANIES
LARGE AGRICULTURE COMPANIES
RNAI DRUG DEVELOPMENT COMPANIES
LARGE REAGENTS COMPANIES
OTHER COMPANIES

Chapter- 10: COMPANIES MENTIONED IN THIS REPORT 14 $854
ABBOTT LABORATORIES
ADVIRNA
AEGERA THERAPEUTICS
AGILENT TECHNOLOGIES
ALNYLAM PHARMACEUTICALS
ANTISENSE PHARMA GMBH
ANTISOMA PLC
APPLIED BIOLOGICAL MATERIALS INC.
ARADIGM CORPORATION
ARCA BIOPHARMA
ARCHEMIX
ARROWHEAD RESEARCH CORPORATION
ASCLETIS INC.
ASTRAZENECA PHARMACEUTICALS LP
ASURAGEN
BENITEC BIOPHARMA LIMITED
BIO-RAD LABORATORIES INC.
BIOGEN IDEC INC.
BIONEER
BRISTOL-MYERS-SQUIBB
CENIX BIOSCIENCE GMBH
CERULEAN PHARMA INC.
CLONTECH LABORATORIES INC.
CONSTAB PHARMACEUTICAL
DEBIOPHARMA
DICERNA PHARMACEUTICALS
DURECT CORPORATION
EXIQON A/S
GENSIGNIA INC.
GLAXOSMITHKLINE
HALO-BIO
ICO THERAPEUTICS INC.
ILLUMINA INC.
INTEGRATED DNA TECHNOLOGIES
ISIS PHARMACEUTICALS
LIFE TECHNOLOGIES (TO BE MERGED WITH THERMO FISHER)
LIQUIDIA TECHNOLOGIES
MARINA BIOTECH
MERCK & CO. INC.
MIRNA THERAPEUTICS
MIRUS BIO LLC
MODERNA THERAPEUTICS INC.
MONSANTO COMPANY
MYRIAD GENETICS INC.
NOVARTIS AG
NOXXON PHARMA AG
OPHTHOTECH
PFIZER INC.
PHARMAXIS LTD
PHASERX
PROGENITOR LABS LIMITED
PROSENSA
QIAGEN NV
QUARK PHARMACEUTICALS INC.
REGADO BIOSCIENCES INC.
REGULUS THERAPEUTICS INC.
ROCHE HOLDING AG
ROSETTA GENOMICS
RXI PHARMACEUTICALS CORP.
SANOFI
SANTARIS PHARMA A/S
SAREPTA THERAPEUTICS
SIGMA-ALDRICH
SILENCE THERAPEUTICS
SYNGENTA AG
TEKMIRA PHARMACEUTICALS CORP
THERMO FISHER SCIENTIFIC INC.

List of Tables

Summary Table : GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, THROUGH 2018
Table 1 : MICRORNA DATABASES
Table 2 : COMPUTATIONAL TOOLS FOR MIRNA TARGET PREDICTION
Table 3 : GLOBAL PHARMACEUTICAL MARKET, MARKET SHARES BY REGION AND TOP COMPANIES
Table 4 : COMPARISON OF U.S. AND EUROPEAN PATENT SYSTEMS
Table 5 : PATENT AND PATENT APPLICATION SEARCHES IN RNAI MARKETPLACE USING VARIOUS KEY WORDS, AS OF AUGUST 2013
Table 6 : PATENTS AND PATENT APPLICATIONS FOR RNAI DRUG COMPANIES, AS OF AUGUST 2013
Table 7 : RECOMMENDED RNAI DELIVERY METHODS
Table 8 : GLOBAL REAGENT AND RESEARCH TOOL FOR DNA AND RNA RESEARCH MARKET, THROUGH 2016
Table 9 : GLOBAL RNAI RESEARCH TOOL AND REAGENT MARKET, THROUGH 2018
Table 10 : MAJOR OBSTACLES FOR RNAI DRUG DELIVERY
Table 11 : RNAI DRUG DELIVERY APPROACHES
Table 12 : PROPRIETARY DELIVERY PLATFORMS
Table 13 : DELIVERY SYSTEMS FROM SILENCE'S INVOLVEMENT
Table 14 : ISIS PHARMACEUTICALS ANTISENSE DRUG CANDIDATES
Table 15 : ISIS PHARMACEUTICALS REVENUE, PROFIT AND STOCK PRICES
Table 16 : RIBOZYME-BASED THERAPIES IN PRECLINICAL CANCER MODELS
Table 17 : APTAMERS AND THEIR TARGETS
Table 18 : APTAMER DRUGS IN VARIOUS CLINICAL STAGES
Table 19 : RNAI THERAPEUTICS TARGETING MICRORNA
Table 20 : SUMMARY OF RNAI-RELATED SOFTWARE
Table 21 : ALNYLAM'S OWN, PARTNERED AND LICENSED PROGRAMS
Table 22 : ARROWHEAD RESEARCH CORPORATION DRUG PIPELINE
Table 23 : RNAI DRUG PIPELINE FROM MARINA BIOTECH
Table 24 : TEKMIRA'S RNAI PIPELINE PROGRAMS
Table 25 : BENITEC IN-HOUSE AND OUT-LICENSED PIPELINES
Table 26 : SILENCE THERAPEUTICS DRUG PIPELINE
Table 27 : BIONEER'S RNAI DRUG PROGRAMS
Table 28 : PHASERX'S PIPELINE PROGRAMS
Table 29 : DICERNA'S EMERGING PIPELINE
Table 30 : RXI PHARMACEUTICALS PIPELINE
Table 31 : QUARK DEVELOPMENT PIPELINE
Table 32 : COMPARISION OF NOTABLE RNA THERAPEUTICS COMPANIES
Table 33 : ESTIMATED MARKET SIZE FOR THERAPEUTIC APPLICATIONS AND GEOGRAPHIC DISTRIBUTION OF RNA DRUG COMPANIES
Table 34 : PUBLICATIONS REGARDING MICRORNA AND DISEASES, AS OF AUGUST 2013
Table 35 : GLOBAL BIOMARKER MARKET, THROUGH 2015
Table 36 : MIRNAS IN VARIOUS CANCER TYPES
Table 37 : MIRNA DYSREGULATION AND COLORECTAL CANCER
Table 38 : STUDIES ON THE ASSOCIATION BETWEEN MIRNA DYSREGULATION AND STAGING OR PROGNOSIS OF COLORECTAL CANCER
Table 39 : MICRORNA UP AND DOWN REGULATION IN LUNG CANCER
Table 40 : IDEAL BIOMARKER CRITERIA
Table 41 : HURDLES TO OVERCOME FOR MICRORNAS TO BE GOOD BIOMARKERS
Table 42 : CANCER PROFILING, THROUGH 2015
Table 43 : GLOBAL MICRORNA RESEARCH MARKET, THROUGH 2017
Table 44 : GLOBAL MICRORNA DIAGNOSTIC AND MICRORNA PROFILING MARKET, THROUGH 2018
Table 45 : NOVEL PLANT TRAITS ENGINEERED THROUGH RNAI

List of Figures

Summary Figure : GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, 2011-2018
Figure 1 : SIMPLIFIED SCHEMATIC REPRESENTATION OF THE RNAI MECHANISM
Figure 2 : THERMO FISHER RNAI PRODUCT SELECTION
Figure 3 : GLOBAL RNAI RESEARCH TOOL AND REAGENT MARKET, 2011-2018
Figure 4 : SCHEMATIC COMPOSITION OF STABLE NUCLEIC ACID LIPID PARTICLE TECHNOLOGY
Figure 5 : MODIFICATIONS TO SIRNA BACKBONES AND BASES
Figure 6 : PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER BACKBONE STRUCTURE
Figure 7 : DESIGNING HIGHLY ACTIVE SIRNAS FOR RNAI THERAPEUTICS
Figure 8 : ROSETTA GENOMICS PIPELINE

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