MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets

 Published On: Oct, 2017 |    No of Pages: 155 |  Published By: BCC Research | Format: PDF
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The global market for microRNA tools reached $756.5 million and $829.8 million in 2015 and 2016, respectively. This market is estimated to reach nearly $1.4 billion in 2021 at a compound annual growth rate (CAGR) of 10.5% for 2016-2021.

Report Includes

-An overview of the global market for microRNA diagnostics and therapeutics, with an analysis of the commercial potential of this research field
-Analyses of global market trends, with data from 2014, 2015, and 2016, and projections of compound annual growth rates (CAGRs) through 2021
-Examination of the extensive portfolio of miRNA pathway drug candidates, some already in Phase II clinical trials, showing promising clinical data in different areas of medicine, such as cancer, hepatitis infections, and cardiovascular diseases
-A focus on recent drug candidates, products, deals between different pharmaceutical companies, major participants, and new trends and developments
-Identification of the main markets for RNA therapeutics

Study Goals and Objectives

Technological advances in genetic engineering and molecular biology have allowed analysis of biological systems at the molecular level. With a rise in awareness of chronic illnesses, cancers and infectious diseases there is an urgent need for efficient diagnostics and better healthcare conditions to treat diseases. As microRNAs play vital roles in biological processes such as immune modulation, metabolic control, neuronal development, cell cycle and stem cell differentiation, they have become a potential target for diagnostic and therapeutic intervention for various diseases. BCC Research’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for microRNA tools.

Increased expenditure on research and development, demands for advanced technology, changes in the global socioeconomic scenario and demand for novel, efficient and cost–effective treatments are accounting for wider application of miRNA tools. The miRNA market is new but is steadily growing and has been one of the most fruitful contributors to modern medicines in recent times. Still in the developmental stage, microRNA (miRNA) research has helped those in the medical sector understand the dynamics of various diseases from a different perception.

This report explores present and future strategies within the miRNA market, which includes miRNA microarray, quantitative reverse transcription PCR (qRT–PCR), next–generation sequencing (NGS), isolation, purification and detection tools, miRNA fluorescence in situ hybridization (miRNA FISH) and other tools, which includes probes, vectors, inhibitors and other analytical tools, among others. The invention of the market, the barriers and the demands of the market are discussed in this report. The classifications, comparisons and usage of these products are also portrayed.

A detailed analysis of the structure of the miRNA tools industry has been conducted. Revenues are broken down by region. Sales figures are estimated for the five–year period from 2016 through 2021. Applications and end users for miRNA are also discussed separately in the report. The report also covers significant patents and their allotments in each category.

Reasons for Doing This Study

MiRNA products are an important part of the biomedical industry. Researchers find major use of miRNA in disease diagnosis, therapeutics and as biomarkers. In diseases like cancer, cardiovascular disorders, immunological disorders and many others, microRNAs act as intracellular mediators as they are necessary for various biological processes. Some miRNAs are overexpressed whereas some are under expressed in a particular disease. In recent years, the role of miRNA in various diseases has been well documented and hence strengthens the candidature of miRNAs to establish as a novel class of drugs, such as miRNA therapeutics.

The largest usage of these technologies has been in the U.S. and Europe and largely for drug development and therapeutic targeting. Modern industries have now begun to explore the advantages of miRNA products in their productions and processes, which has led to a steady market.

Research and development spending, along with increasing competition and new technologies are giving a direction to the market. The advancements, new product launches and changing lifestyles have influenced the future growth of the market. This study addresses systems affected by these factors.

Acquisition strategies and collaborations are also covered in this report, as well as the strengths and weaknesses of each type in light of the new technologies, growing competition, and changing customer needs.

Scope of Report

This report focuses on the global market of miRNA tools and provides an updated review including its applications in various arenas of diagnostics and therapeutics. The report deals with miRNA tools covering technologies used in the biomedical industry. These products are miRNA microarray, quantitative reverse transcription–PCR, next–generation sequencing, fluorescent in situ hybridization, isolation, purification, detection tools and other tools like inhibitors, probes and vectors.

The report also covers miRNA tools by end user and applications. The end users for miRNA tools are categorized as research, diagnostics, therapeutics, and service sectors. The report covers market application areas, such as cancer diseases, cardiovascular diseases, immunological diseases, neurological diseases, metabolic disorders and others (virology, endocrinology, plant science and genetic disease fields).

The scope of the study is global. BCC Research analyzes each market and its application, new products and advancements, market projections and market shares. The geographical regions covered in the report are the United States, Europe and emerging markets. The emerging market covers countries such as India, China, Japan, Korea, Taiwan, Africa, Australia, New Zealand, and Canada among others.

Also included in the report are relevant patent analysis, new products and developments and comprehensive profiles of companies that lead the industry. Notable players in this category are Thermo Fisher Scientific, Agilent Technologies, Qiagen N.V., Illumina Inc., F. Hoffmann–La Roche AG, and Bio– Rad Laboratories Inc.

Information Sources

Many companies were surveyed to obtain data for this study. Included were manufacturers and end users of miRNA products. Data was gathered from various industry sources. BCC Research spoke with officials within the industry, consulted newsletters, company literature, product literature, and a host of technical articles, journals, indexes, and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade, and government sources.

Methodology

Both primary and secondary research methodologies were used in preparing this study. BCC Research conducted a comprehensive literature search, which included technical newsletters and journals, as well as many other sources. Data was collected through interviews and correspondence with manufacturers and users of miRNA tool products. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

Geographic Breakdown

In this report, the geographic regions considered for market analysis include, and only include:

The United States
Europe
Western European countries.
Eastern European Countries.

Emerging Markets
China.
India.
Japan.
Korea.
Taiwan.
Africa.
Australia.
New Zealand.
Canada.
Chapter 1: Introduction 2
Study Goals and Objectives 2
Reasons for Doing This Study 2
Scope of Report 3
Information Sources 3
Methodology 4
Geographic Breakdown 4
Analyst's Credentials 8
Related BCC Research Reports 8

Chapter 2: Summary and Highlights 10

Chapter 3: Market and Technology Background 14
Some Related Terms 14
Eukaryotes 14
Genes 14
Genetic Engineering 14
Prokaryotes 14
Transcription 14
Translation 14
Introduction 14
Overview 15
Background– Genetic Material 15
Types of RNA 16
Messenger RNA (mRNA) 17
Ribosomal RNA (rRNA) 17
Transfer RNA (tRNA) 17
MicroRNAs (miRNA) 17
Small Interfering RNAs (siRNA) 17
Small Nucleolar RNA (snoRNA) 17
History of MicroRNA Research Tools 18
Biogenesis of MicroRNA 19
The Function of MicroRNA 21
MicroRNAs Associated with Human Diseases 21
Role of microRNAs In Various Diseases 24
Applications of MicroRNA 25
Research Tools 25
MicroRNA in Therapeutics 26
More on MicroRNA in Therapeutics 28
MicroRNA in Diagnostics 29
MicroRNA Service Providers 31
MicroRNA Tools and Technologies 32
MiRNA Isolation Tools 33
MiRNA Microarray Tools 33
Reverse Transcription–Quantitative PCR (RT–qPCR) 34
Next–Generation Sequencing 35
MicroRNA Fluorescence in Situ Hybridization (miRNA FISH) 35
Bioinformatics: Applications in MicroRNA Research 36
Computational Tools 36
miRanda 36
MiRanda– mirSVR 37
TargetScan 37
DIANA–micro T–CDS 37
MirTarget2 37
rna–22–GUI 37
TargetMiner 37
SVMicrO 38
Probability of Interaction by Target Accessibility (PITA) 38
RNAhybrid 38
MicroRNA Databases 38
miRBase Database 38
DeepBase 39
microRNA.org 39
MiRGen 3.0 40
MiRNAMap 40
Plant Microrna Database (PMRD) 40

Chapter 4: Market Breakdown by Technology Type 42
Market by Type 42
Market Overview 43
Market Revenue 44
Market Share 46
Bioinformatics: Applications in MicroRNA Research 47
Market Overview 47
Market Revenue 48
Market Share 49

Chapter 5: Market Breakdown by End User 52
Global MiRNA Market by End Users 52
Research 52
Therapeutics 52
Diagnostics 53
Service 53
Market Overview 53
Market Revenue 54
Market Share 56
MicroRNA Tools Used for Research 57
MicroRNA Tools Used for Therapeutics 59
MicroRNA Tools Used by the Service Sector 62
MicroRNA Tools Used for Diagnostic 65

Chapter 6: Market Breakdown by Application 70
Global Market for MicroRNA Tools by Application 71
Market Overview 71
Market Revenue 72
Market Share 73
MicroRNA Tools Used for Cancer Diseases 74
MicroRNA Tools Used for Cardiovascular Diseases 77
MicroRNA Tools Used for Immunological Diseases 80
MicroRNA Tools Used for Neurological Diseases 82
MicroRNA Tools Used for Metabolic Disorders 84
MicroRNA Tools Used for Other Applications 87

Chapter 7: Market Breakdown by Region 91
Market Overview 91
Market Revenue 92
Market Share 94
MicroRNA Microarray 95
Market Overview 95
Market Revenue 96
Quantitative Reverse Transcription Polymerase Chain Reaction (qRT–PCR) 97
Market Overview 98
Market Revenue 98
Next-Generation Sequencing (NGS) 100
Market Overview 101
Market Revenue 101
Isolation, Purification and Detection Tools 102
Market Overview 103
Market Revenue 103
MicroRNA Fluorescence in Situ Hybridization (MiRNA FISH) 105
Market Overview 105
Market Revenue 105
Other Tools 107
Market Overview 108
Market Revenue 108

Chapter 8: Industry Structure 111
MicroRNA Microarray 111
Market Leaders 111
Market Share 112
Quantitative Reverse Transcription Polymerase Chain Reaction (QRT–PCR) 113
Market Leaders 113
Market Share 114
Next–Generation Sequencing (NGS) 116
Market Leaders 116
Market Share 116
Isolation, Purification & Detection Tools 118
Market Leaders 118
Market Share 118
MicroRNA Fluorescence in Situ Hybridization (FISH) 120
Market Leaders 120
Market Share 121
Other Tools 122
Market Leaders 122
Market Share 123

Chapter 9: Patent Review/ New Developments 125
Patents by Year 125
Patents by Type 126
Patents by Company 127
Patents by Country 129
Patents by Assignee 131
New Products and Developments 132
Pipeline Products 135
Mergers and Acquisitions 137
Awards for MicroRNA Tools 137

Chapter 10: Analysis of Market Opportunities 140
Factors Affecting the MicroRNA Market 141
Drivers of the MicroRNA Tools Market 141
Current Challenges for the MicroRNA Tools Market 142

Chapter 11: Company Profiles 144
Appendix: Abbreviations 169
About BCC Research 172
About BCC Research 173
BCC Membership 173
BCC Custom Research 173

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